RT Journal Article
T1 Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression
A1 Lage Fernández, Ricardo
A1 Parisi, Claudia
A1 Seoane Collazo, Patricia
A1 Fernø, Johan
A1 Mazza, Roberta
A1 Bosch, Fátima
A1 Seoane, Luisa M.
A1 Diéguez González, Carlos
A1 Quarta, Carmelo
A1 López Pérez, Miguel A.
K1 CART
K1 CB1
K1 Food intake
K1 Hypothalamus
K1 POMC
AB Background:Cumulative data indicate that the endocannabinoid system plays a major role in feeding behavior and energy balance. Genetic silencing of cannabinoid receptor type 1 (CB1) reduces body weight gain, independently of food intake.Methods:In this work, we investigated whether the hypothalamic neuropeptide expression pattern supports the absence of the anorexigenic response observed under constitutive CB1 ablation, by using neuronal CB1 conditional null mice (CamK-CB1-KO) and whole body CB1 null mice (CB1-KO).Results:Our data showed that both CB1 null models display a marked decrease in proopiomelanocortin (POMC) and cocaine-amphetamine-regulated transcript (CART) expression in the arcuate nucleus of the hypothalamus (ARC).Conclusions:This evidence suggests that a lack of hypophagia is associated with the suppression of ARC anorexigenic neuropeptides and that behavioral changes in food intake (or lack thereof) after constitutive CB1 ablation are likely mediated by impaired melanocortin and CART signaling in the hypothalamus.
PB Oxford University Press
SN 1461-1457
YR 2015
FD 2015
LK http://hdl.handle.net/10347/23057
UL http://hdl.handle.net/10347/23057
LA eng
NO Lage, R., Parisi, C., Seoane-Collazo, P., Fernø, J., Mazza, R., & Bosch, F. et al. (2015). Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression. International Journal Of Neuropsychopharmacology, 18(9), pyv011. doi: 10.1093/ijnp/pyv011
NO The research leading to these results has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement nº 281854 of the ObERStress European Research Council Project (Dr López) and 245009 of the Neurofast project (Drs Nogueiras, Diéguez, and López); Xunta de Galicia (Dr Nogueiras: EM 2012/039 and 2012-CP069; Dr López: 2012-CP070); the Frank Mohn Foundation, Bergen (Dr Fernø); Instituto de Salud Carlos III (ISCIII; Dr López: PI12/01814 and PIE13/00024); and MINECO, co-funded by the FEDER Program of EU (Dr Nogueiras: RyC-2008-02219 and BFU2012-35255; Dr Diéguez: BFU2011-29102). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII
DS Minerva
RD 27 abr 2026