RT Journal Article
T1 Reduced anterior prefrontal cortex activation in young binge drinkers during a visual working memory task
A1 Crego Barreiro, Manuel Alberto
A1 Rodríguez Holguín, Socorro
A1 Parada Iglesias, María
A1 Mota Miranda, Nayara Graciella
A1 Corral Varela, María Montserrat
A1 Cadaveira Mahía, Fernando
K1 ERP
K1 eLORETA
K1 Binge drinking
K1 College students
K1 Working memory
K1 Prefrontal cortex
AB Working memory (WM) is a major cognitive function that is altered by chronic alcohol consumption. This impairment has been linked to alterations in the hippocampus and prefrontal cortex (PFC). Animal and human studies have shown that the adolescent brain is more sensitive to the neurotoxic effects of alcohol than the adult brain, particularly those structures that mature late on in development, such as the hippocampus and prefrontal brain. The aim of the present study was to assess visual working memory and its neural correlates in young university students who partake in intermittent consumption of large amounts of alcohol (binge drinkers). A sample of 42 binge drinkers and 53 corresponding control subjects performed an identical pairs continuous performance task (IP-CPT) in a combined Event-Related Potential (ERP) and exact Low-Resolution brain Electromagnetic Tomography (eLORETA) study. The results revealed that, despite adequate performance, binge drinkers showed a smaller late positive component (LPC) associated with hypoactivation of the right anterior prefrontal cortex (aPFC) for matching stimuli, in comparison with control subjects. These findings may reveal binge drinking-related functional alteration in recognition working memory processes and suggest that impaired prefrontal cortex function may occur at an early age in binge drinkers
PB Elsevier
SN 0376-8716
YR 2010
FD 2010
LK http://hdl.handle.net/10347/16798
UL http://hdl.handle.net/10347/16798
LA eng
NO Crego A, Rodríguez Holguín S, Parada M, Mota N, Corral M, Cadaveira F (2009). Reduced anterior prefrontal cortex activation in young binge drinkers during a visual working memory task. Drug and Alcohol Dependence, 109, 45-56. doi:10.1016/j.drugalcdep.2009.11.020
NO This is the accepted manuscript of the following article: Crego A, Rodríguez Holguín S, Parada M, Mota N, Corral M, Cadaveira F (2010). Reduced anterior prefrontal cortex activation in young binge drinkers during a visual working memory task. Drug and Alcohol Dependence, 109, 45-56. doi:10.1016/j.drugalcdep.2009.11.020
NO This research was supported by Consellería de Innovación e Industria of Xunta de Galicia, grant number PGIDIT05CSO21103PR and INCITE08PXIB211015PR, by Plan Nacional sobre Drogas(PND) of Ministerio de Salud y Consumo of Spain, grant number 2005/PN014, and by Ministerio de Ciencia e Innovación of Spain, grant ref. EDU2008-03400. The Consellería de Innovación e Industria of Xunta de Galicia, PND of Ministerio de Salud y Consumo of Spain and Ministerio de Ciencia e Innovación of Spain had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the paper for publication
DS Minerva
RD 24 abr 2026