RT Journal Article
T1 Current Situation and Challenges in Vitreous Substitutes
A1 Mondelo García, Cristina
A1 Bandín Vilar, Enrique
A1 García Quintanilla, Laura
A1 Castro Balado, Ana
A1 Amo, Eva María del
A1 Gil Martínez, María
A1 Blanco Teijeiro, María José
A1 González Barcia, Luis
A1 Zarra Ferro, Irene
A1 Fernández Ferreiro, Anxo
A1 Otero Espinar, Francisco Javier
K1 Biomaterials
K1 Hydrogels
K1 Perfluorocarbon liquids
K1 Silicone oils
K1 Vitreous substitution
AB Vitreo-retinal disorders constitute a significant portion of treatable ocular diseases. These pathologies often require vitreo-retinal surgery and, as a consequence, the use of vitreous substitutes. Nowadays, the vitreous substitutes that are used in clinical practice are mainly divided into gases (air, SF6, C2F6, C3F8) and liquids (perfluorocarbon liquids, silicone oils, and heavy silicone oils). There are specific advantages and drawbacks to each of these, which determine their clinical indications. However, developing the ideal biomaterial for vitreous substitution continues to be one of the most important challenges in ophthalmology, and a multidisciplinary approach is required. In this sense, recent research has focused on the development of biocompatible, biodegradable, and injectable hydrogels (natural, synthetic, and smart), which also act as medium and long-term internal tamponade agents. This comprehensive review aims to cover the main characteristics and indications for use of the extensive range of vitreous substitutes that are currently used in clinical practice, before going on to describe the hydrogels that have been developed recently and which have emerged as promising biomaterials for vitreous substitution
PB Wiley
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26224
UL http://hdl.handle.net/10347/26224
LA eng
NO Mondelo-García, C., Bandín-Vilar, E., García-Quintanilla, L., Castro-Balado, A., del Amo, E.M., Gil-Martínez, M., Blanco-Teijeiro, M.J., González-Barcia, M., Zarra-Ferro, I., Fernández-Ferreiro, A. and Otero-Espinar, F.J. (2021), Current Situation and Challenges in Vitreous Substitutes. Macromol. Biosci. 2100066. https://doi.org/10.1002/mabi.202100066
NO C.M.-G., E.B.-V., L.G.-Q., and A.F.-F. are grateful to the Carlos III Health Institute for financing the CM18/00090, CM20/00135, CM20/00024, and JR18/00014 personnel contracts. This work was partially supported by the following projects of Carlos III Health Institute (PI17/00940 and PI20/00719)
DS Minerva
RD 28 abr 2026