RT Journal Article
T1 Changes in visual memory in mild cognitive impairment: a longitudinal study with CANTAB
A1 Campos Magdaleno, María
A1 Leiva, David
A1 Pereiro Rozas, Arturo X.
A1 Lojo Seoane, Cristina
A1 Mallo López, Sabela Carme
A1 Facal Mayo, David
A1 Juncos Rabadán, Onésimo
K1 Visual memory
K1 CANTAB tests
K1 Mild cognitive impairment
K1 Linear mixed models
K1 Longitudinal assessment
AB Background: Mild cognitive impairment (MCI), as a stage in the cognitive continuum between normal aging and dementia, is mainly characterized by memory impairment. The aims of this study were to examine CANTAB measures of temporal changes of visual memory in MCI and to evaluate the usefulness of the baseline scores for predicting changes in cognitive status.Methods: The study included 201 participants aged over 50 years with subjective cognitive complaints. Visual memory was assessed with four CANTAB tests (PAL, DMS, PRM and SSP) administered at baseline and on two further occasions, with a follow-up interval of 18-24 months. Participants were divided into three groups according to the change in their cognitive status: participants with subjective cognitive complaints who remained stable (SCC-Stable), MCI participants who remained stable (MCI-Stable) and MCI participants whose cognitive deterioration  continued (MCIWorsened). Linear Mixed Models were used to model longitudinal changes, with evaluation time as a fixed variable, and multinomial regression models were used to predict changes in cognitive status.Results: Isolated significant effects were obtained for Age and Group with all CANTAB tests used. Interactions between Evaluation Time and Group were identified in the PAL and DMS tests, indicating different temporal patterns depending on the changes in cognitive status. Regression models also indicated that CANTAB scores were good predictors of changes in cognitive status.Conclusions: Decline in visual memory measured by PAL and DMS tests can successfully distinguish different types of MCI, and considered together PAL, DMS, PRM and SSP can predict changes in cognitive status.
YR 2020
FD 2020
LK http://hdl.handle.net/10347/32818
UL http://hdl.handle.net/10347/32818
LA eng
NO Campos-Magdaleno, M., Leiva, D., Pereiro, A.X., Lojo-Seoane, C., Mallo, S.C., Facal, D., Juncos-Rabadán, O. (2021).Changes in visual memory in mild cognitive impairment: a longitudinal study with CANTAB. Psychological Medicine 51, 2465–2475.
NO This research was supported through FEDER founds by the Spanish Directorate General of Scientific and Technical Research (Project Ref. PSI2014-55316-C3-1-R), the National Research Agency (Spanish Ministry of Science, Innovation and Universities) (Project Ref. PSI2017-89389-C2-1-R) and by theGalician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema Universitario de Galicia;GI-1807-USC:Ref.ED431-2017/27).
DS Minerva
RD 28 abr 2026