RT Journal Article
T1 Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients
A1 Candal Pedreira, Cristina
A1 Ruano Raviña, Alberto
A1 Provencio, Mariano
K1 Characteristics
K1 Genetic alterations
K1 Lung cancer
K1 Young patients
K1 Epidermal growth factor receptor
K1 Anaplastic lymphoma kinase
AB IntroductionThe aim of this study was to analyze the clinical and genetic characteristics of young lung cancer cases, and to compare them with those of older cases.MethodsWe used the Thoracic Tumors Registry (TTR) as a data source representative of lung cancer cases diagnosed in Spain, and included all cases registered until 9/01/2023 which had information on age at diagnosis or the data needed to calculate it. We performed a descriptive statistical analysis and fitted logistic regressions to analyze how different characteristics influenced being a younger lung cancer patient.ResultsA total of 26,336 subjects were included. Lung cancer cases <50 years old had a higher probability of being women (OR: 1.38; 95% CI: 1.21–1.57), being in stage III or IV (OR: 1.32; 95% CI: 1.08–1.62), not having comorbidities (OR: 5.21; 95% CI: 4.59–5.91), presenting with symptoms at diagnosis (OR: 1.53; 95% CI: 1.29–1.81), and having ALK translocation (OR: 7.61; 95% CI: 1.25–46.32) and HER2 mutation (OR: 5.71; 95% CI: 1.34–24.33), compared with subjects ≥50 years. Among subjects <35 years old (n = 61), our study observed a higher proportion of women (59.0% vs. 26.6%; p < 0.001), never smokers (45.8% vs. 10.3%; p < 0.001), no comorbidities (21.3% vs. 74.0%; p < 0.001); ALK translocation (33.3% vs. 4.4%; p < 0.001) and ROS1 mutation (14.3% vs. 2.3%; p = 0.01), compared with subjects ≥35 years.ConclusionsLung cancer displays differences by age at diagnosis which may have important implications for its clinical management.
PB Elsevier
SN 0300-2896
YR 2024
FD 2024
LK http://hdl.handle.net/10347/33081
UL http://hdl.handle.net/10347/33081
LA eng
NO Archivos de Bronconeumología Volume 60, Issue 2, February 2024, Pages 88-94
DS Minerva
RD 25 abr 2026