RT Journal Article
T1 CARTAR: a comprehensive web tool for identifying potential targets in chimeric antigen receptor therapies using TCGA and GTEx data
A1 Hernández Gamarra, Miguel
A1 Salgado Roo, Alba
A1 Domínguez Medina, Eduardo
A1 Goiricelaya Seco, Elena María
A1 Veiga Rúa, Sara
A1 Fernández Pedrera Garbayo, Lucía
A1 Carracedo Álvarez, Ángel
A1 Allegue Toscano, Catarina
K1 CAR
K1 Target selection
K1 Immunotherapy
K1 Web tool
K1 Logic-gated
AB Chimeric antigen receptor (CAR) therapy has emerged as a ground-breaking advancement in cancer treatment, harnessing the power of engineered human immune cells to target and eliminate cancer cells. The escalating interest and investment in CAR therapy in recent years emphasize its profound significance in clinical research, positioning it as a rapidly expanding frontier in the field of personalized cancer therapies. A crucial step in CAR therapy design is choosing the right target as it determines the therapy’s effectiveness, safety and specificity against cancer cells, while sparing healthy tissues. Herein, we propose a suite of tools for the identification and analysis of potential CAR targets leveraging expression data from The Cancer Genome Atlas and Genotype-Tissue Expression Project, which are implemented in CARTAR website. These tools focus on pinpointing tumor-associated antigens, ensuring target selectivity and assessing specificity to avoid off-tumor toxicities and can be used to rationally designing dual CARs. In addition, candidate target expression can be explored in cancer cell lines using the expression data for the Cancer Cell Line Encyclopedia. To our best knowledge, CARTAR is the first website dedicated to the systematic search of suitable candidate targets for CAR therapy. CARTAR is publicly accessible at https://gmxenomica.github.io/CARTAR/
PB Oxford Academic
YR 2024
FD 2024-07-04
LK http://hdl.handle.net/10347/34844
UL http://hdl.handle.net/10347/34844
LA eng
NO Briefings in Bioinformatics, 2024, 25(4), bbae326
NO This work was supported by grants from Xunta de Galicia (ED431G 2019/02; ED481A 2022)
DS Minerva
RD 28 abr 2026