RT Journal Article
T1 Diagnostic Cut-Off Values Based on Lipid Layer Pattern for Dry Eye Disease Subtypes Assessment
A1 Sabucedo Villamarín, Belén
A1 García Queiruga, Jacobo
A1 Pena Verdeal, Hugo
A1 García Resúa, Carlos
A1 Yebra-Pimentel Vilar, Eva
A1 Giráldez Fernández, María Jesús
K1 Lipid Layer Pattern
K1 Aqueous Deficient Dry Eye
K1 Evaporative Dry Eye
K1 Mixed Dry Eye
K1 cut-off value
AB Background: The aim of the present study was to establish a cut-off value of the Lipid Layer Pattern (LLP) between participants with different subtypes of Dry Eye Disease (DED) including Deficient Dry Eye (ADDE), Evaporative Dry Eye (EDE), and Mixed Dry Eye (MDE). Methods: 240 participants diagnosed with DED according to the Tear Film and Ocular Surface Society in the Dry Eye Workshop II guidelines were included in the study. Tear Meniscus Height (TMH) using the Tearscope illumination and Meibomian Gland Loss Area (MGLA) using the Keratograph 5M were assessed to categorize the participants into an ADDE group, EDE group, or MDE group. Then, theLLP was assessed using the Tearscope following the Guillon (LLP-G) and Colour (LLP-C) schemes. Results: Receiver Operating Characteristics (ROC) showed that both LLP-G and LLP-C have no diagnostic potential in distinguishing between ADDE and EDE participants (both p ≥ 0.724). However, to differentiate the ADDE participants from the MDE, ROC procedures showed a good diagnostic potential with cut-off values of Closed Meshwork- Wave (AUC ± SD = 0.609 ± 0.049, p = 0.038, sensitivity: 23.9%; specificity: 76.1%) and Grey-White (AUC ± SD = 0.611 ± 0.050, p = 0.034, sensitivity: 40.7%; specificity: 73.9%) for LLP-G and LLP-C, respectively. Also, a significant potential to distinguish between the EDE from MDE participants was found, with cut-off values of Closed Meshwork (AUC ± SD = 0.604 ± 0.049, p = 0.043, sensitivity: 40.8%; specificity: 76.1%) and Grey- White (AUC ± SD = 0.604 ± 0.051, p = 0.038, sensitivity: 44.7%; specificity: 73.9%) for LLP-G and LLP-C, respectively. Conclusions: Using the Tearscope, both LLP-G and LLP-C has diagnostic potential to distinguish MDE participants from the other subtypes of DED.
PB MDPI
YR 2025
FD 2025-01-19
LK https://hdl.handle.net/10347/38794
UL https://hdl.handle.net/10347/38794
LA eng
NO Sabucedo-Villamarin, B.; Garcia-Queiruga, J.; Pena-Verdeal, H.; Garcia-Resua, C.; Yebra-Pimentel, E.; Giraldez, M.J. Diagnostic Cut-Off Values Based on Lipid Layer Pattern for Dry Eye Disease Subtypes Assessment. J. Clin. Med. 2025, 14, 623. https://doi.org/10.3390/jcm14020623
DS Minerva
RD 23 abr 2026