RT Journal Article
T1 Engineered cell membrane-cloaked metal-organic framework nanocrystals for intracellular cargo delivery
A1 Migliavacca, Martina
A1 Cedrún Morales, Manuela
A1 Ceballos Guzmán, Manuel
A1 Soprano, Enrica
A1 Polo Tobajas, Ester
A1 Pelaz García, Beatriz
A1 Pino González de la Higuera, Pablo Alfonso del
K1 NMOF
K1 Nanocristales
K1 Transporte  intracelular
K1 Recubrimientos celulares
AB This investigation demonstrates the development and functionality of cell membrane-cloaked UiO-67 nanosized metal–organic frameworks (NMOFs), which are engineered for precise intracellular delivery of encapsulated cargoes. Utilizing the robust and porous nature of UiO-67, we enveloped these NMOFs with fusogenic cell membrane-derived nanovesicles (FCSMs) sourced from adenocarcinomic human alveolar basal epithelial (A549) cells. This biomimetic coating enhances biocompatibility and leverages the homotypic targeting capabilities of the cell-derived coatings, facilitating direct cytoplasmic delivery and avoiding endolysosomal entrapment. Our nanoplatform exhibited high efficiency in loading and releasing two model cargoes: cresyl violet (CV), a staining agent, and carboplatin (CbPt), a chemotherapeutic agent. This approach demonstrated substantial potential in drug delivery in both 2D cell cultures and 3D spheroids. This study underscores the enhanced cellular uptake facilitated by the engineered biomimetic shell and highlights the system’s capacity for sustained release, offering a promising strategy for targeted drug delivery
PB Elsevier
SN 0021-9797
YR 2024
FD 2024-11-23
LK https://hdl.handle.net/10347/40003
UL https://hdl.handle.net/10347/40003
LA eng
NO Migliavacca, M., Cedrún-Morales, M., Ceballos, M., Soprano, E., Polo, E., Pelaz, B., Del Pino, P. (2024). Engineered cell membrane-cloaked metal-organic framework nanocrystals for intracellular cargo delivery. "Journal Of Colloid And Interface Science", vol. 682, 31-40
NO The authors thank the financial support of the European Research Council (starting grant #950421), the European Union (European Union NextGeneration EU/PRTR; H2020-MSCA-ITN #860942), the MICIU/AEI/https://doi.org/10.13039/501100011033(PID2022-142338OB- 100, PID2020-119206RB-I00, PID2020-119479RA-I00, RYC-2019- 028238-I), and the Xunta de Galicia (#ED431F-2021/02, #2021- CP090, #ED431B 2023/19, #ED431C 2022/18, and Centro de Inves tigaci´on do Sistema Universitario de Galicia accreditation 2023–2027 #ED431G 2023/03). M.C-M. thanks the AEI (FPU19/03155)
DS Minerva
RD 8 jun 2026