RT Journal Article
T1 Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin
A1 López Iglesias, Clara
A1 Barros, Joana
A1 Ardao Palacios, Inés
A1 Gurikov, Pavel
A1 Monteiro, Fernando J.
A1 Smirnova, Irina
A1 Álvarez Lorenzo, Carmen
A1 García González, Carlos A.
K1 Biopolymers
K1 Polymer Processing
K1 Biomedical Applications
K1 Wound Treatment
K1 Chitosan
K1 Aerogels
AB Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/21688
UL http://hdl.handle.net/10347/21688
LA eng
NO López-Iglesias, C.; Barros, J.; Ardao, I.; Gurikov, P.; Monteiro, F.J.; Smirnova, I.; Alvarez-Lorenzo, C.; García-González, C.A. Jet Cutting Technique for the Production of Chitosan Aerogel Microparticles Loaded with Vancomycin. Polymers 2020, 12, 273.
NO This research was funded by the Xunta de Galicia [ED431F 2016/010 & ED431C 2016/008], MCIUN [RTI2018-094131-A-I00], Agrupación Estratégica de Materiales [AeMAT-BIOMEDCO2, ED431E 2018/08], Agencia Estatal de Investigación [AEI] and FEDER funds. C.A.G.-G. acknowledges MINECO for a Ramón y Cajal Fellowship [RYC2014-15239]. Work was carried out in the frame of the COST Action CA18125 “Advanced Engineering and Research of aeroGels for Environment and Life Sciences” (AERoGELS) and funded by the European Commission
DS Minerva
RD 27 abr 2026