RT Journal Article
T1 Transgenerational inheritance of chemical-induced signature: A case study with simvastatin
A1 Neuparth, Teresa
A1 Machado, André M.
A1 Montes Goyanes, Rosa
A1 Rodil Rodríguez, María del Rosario
A1 Barros, Susana
A1 Alves, Nélson
A1 Ruivo, Raquel
A1 Castro, Luis Filipe
A1 Quintana Álvarez, José Benito
A1 Santos, Miguel Machado
K1 Simvastatin
K1 Transgenerational effects
K1 Reproduction
K1 Transcriptomic
K1 Epigenetics
K1 Regulatory agencies
AB The hypothesis that exposure to certain environmental chemicals during early life stages may disrupt reproduction across multiple non-exposed generations has significant implications for understanding disease etiology and adverse outcomes. We demonstrate here reproductive multi and transgenerational effects, at environmentally relevant levels, of one of the most prescribed human pharmaceuticals, simvastatin, in a keystone species, the amphipod Gammarus locusta. The transgenerational findings has major implications for hazard and risk assessment of pharmaceuticals and other contaminants of emerging concern given that transgenerational effects of environmental chemicals are not addressed in current hazard and risk assessment schemes. Considering that the mevalonate synthesis, one of the key metabolic pathways targeted by simvastatin, is highly conserved among metazoans, these results may also shed light on the potential transgenerational effects of simvastatin on other animals, including humans.
PB Elsevier
SN 0160-4120
YR 2020
FD 2020
LK http://hdl.handle.net/10347/26080
UL http://hdl.handle.net/10347/26080
LA eng
NO Environment International 144 (2020) 106020
NO This research was funded by COMPETE 2020, Portugal 2020, the European Union through the ERDF and the Portuguese Foundation for Science and Technology – FCT (Transobesogen project – Trans-phyletic obesogenic responses: from epigenetic modules to transgenerational environmental impacts, reference: PTDC/CTA-AMB/31544/2017 – NORTE-01-0145-FEDER-031544). This research was also supported by the National Funds through FCT under the projects (UIDB/04423/2020; UIDP/04423/2020), by the Spanish Agencia Estatal de Investigación (CTM2017-84763-C3-2-R), and by the Galician Council of Culture, Education and Universities (ED431C2017/36), cofounded by ERDF. A PhD grant awarded to Susana Barros (PD/BD/143090/2018) was funded by the FCT
DS Minerva
RD 29 abr 2026