RT Journal Article
T1 pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets
A1 Méndez Ardoy, Alejandro
A1 Granja Guillán, Juan Ramón
A1 Montenegro García, Javier
AB The controlled one-dimensional supramolecular polymerization of synthetic building blocks in confined spaces constitutes a key challenge to simplify the understanding of the fundamental physical principles behind the behavior of more complex encapsulated polymer networks. Cyclic peptide nanotubes constitute an optimal scaffold for the fabrication of hierarchical one-dimensional self-assembled architectures. Herein we report the pH-controlled nanotube formation and fibrillation of supramolecular cyclic peptides in confined aqueous droplets. The externally triggered self-assembly of these peptides gave rise to viscoelastic hydrogels in which the one-dimensional molecular arrangement was perfectly preserved from the nano- to the micro-scale. The cyclic peptide building blocks were confined inside water microdroplets and the base-triggered supramolecular polymerization was externally triggered and followed by confocal microscopy showing that the confined fibrillation spanned and affected the shape of the droplet micro container
PB Royal Society of Chemistry
SN 2055-6756
YR 2018
FD 2018-04-03
LK http://hdl.handle.net/10347/16691
UL http://hdl.handle.net/10347/16691
LA eng
NO Méndez-Ardoy, A., Granja, J., & Montenegro, J. (2018). pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets. Nanoscale Horizons. http://dx.doi.org/10.1039/c8nh00009c
NO This is the Accepted Manuscript of the following article: Méndez-Ardoy, A., Granja, J., & Montenegro, J. (2018). pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets. Nanoscale Horizons. http://dx.doi.org/10.1039/c8nh00009c
NO This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI) [SAF2017-89890-R, CTQ2014-59646-R and CTQ2016-78423-R], the Xunta de Galicia(ED431G/09, ED431C 2017/25 and 2016-AD031) and the ERDF. A. M.-A. received a MCIF from the EC (GLYCONANOPEP-750248).J. M. holds a Ramón y Cajal (RYC-2013-13784), an ERC-Stg (DYNAP-677786) and a Young Investigator Grant from the HFSP (RGY0066/2017)
DS Minerva
RD 24 abr 2026