RT Journal Article
T1 Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review
A1 Koidou, V.P.
A1 Chatzopoulos, G.S.
A1 Tomás Carmona, Inmaculada
A1 Nibali, L.
A1 Donos, Nikolaos
K1 Gingival crevicular fluid
K1 Markers
K1 Guided tissue regeneration
K1 Open flap debridement
AB Background: Surgical treatments such as guided tissue regeneration (GTR) and access flap surgery are widely employed for thetreatment of intrabony defects. However, little is known regarding the postoperative expression of gingival crevicular fluid (GCF)markers.Objective: The aim of this systematic review was to compare the expression of GCF markers following treatment of periodontalintrabony defects with guided tissue regeneration or access surgery. The association of the markers’ expression with the clinicaloutcome was also assessed.Methods: An electronic literature search was conducted in MEDLINE, EMBASE, OpenGrey, LILACS and Cochrane Library upto December 2018 complemented by a manual search. Human, prospective clinical studies were identified. The changes frombaseline up to 30 days (early healing) and 3 months (late healing) were assessed.Results: A total of 164 publications were identified and reviewed for eligibility. Of these, 10 publications fulfilled the inclusioncriteria. The included studies evaluated 15 different GCF markers with a follow-up time between 21 and 360 days postoperatively.PDGF, VEGF and TIMP-1 changes were often investigated in the included studies; however, contrasting results werereported. Two studies agreed that both GTR and OFD lead to similar OPG level changes. TGF-β1 is increased early postoperatively,irrespective of the surgical technique employed.Conclusión: There is limited evidence available on the expression of GCF markers after surgical interventions of intrabonyperiodontal defects. However, OPG and TGF-β1 tend to increase early post-operatively, irrespective of the surgical techniqueemployed, irrespective of the surgical technique employed.Clinical relevance: More well-designed, powered studies with sampling periods reflecting the regenerative process are needed,and future research should focus on employing standardised protocols for collecting, storing and analysing GCF markers
PB Springer
SN 1432-6981
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21252
UL http://hdl.handle.net/10347/21252
LA eng
NO Koidou, V.P., Chatzopoulos, G.S., Tomas, I. et al. Expression of gingival crevicular fluid markers during early and late healing of intrabony defects after surgical treatment: a systematic review. Clin Oral Invest 24, 487–502 (2020). https://doi.org/10.1007/s00784-019-03088-4
DS Minerva
RD 24 abr 2026