RT Journal Article
T1 World Workshop on Oral Medicine VIII: Development of a core outcome set for oral lichen planus: a systematic review of outcome domains
A1 López Pintor, Rosa María
A1 Diniz Freitas, Márcio
A1 Ramesh, Shilpa Shree Kuduva
A1 Valdez, J. Amadeo
A1 Dan, Hongxia
A1 Bissonnette, Caroline
A1 Hong, Catherine
A1 Farag, Arwa
A1 Greenberg, Martin S.
A1 Brennan, Michael T.
A1 Burkhart, Nancy
A1 Setterfield, Jane F.
A1 Woo, Sook-Bin
A1 Sollecito, Thomas P.
A1 Ní Ríordáin, Rícheal
A1 Taylor, Jennifer
A1 Robledo Sierra, Jairo
AB Objective: There is a lack of consensus regarding clinician- and patient-reported oral lichen planus (OLP) outcomes. The World Workshop on Oral Medicine Outcomes Initiative for the Direction of Research (WONDER) Project aims to develop a core outcome set (COS) for OLP, which would inform the design of clinical trials and, importantly, facilitate meta-analysis, leading to the establishment of more robust evidence for the management of this condition and hence improved patient care.Study Design: Ovid MEDLINE, Embase, CINAHL, CENTRAL, and Clinicaltrials.gov were searched for interventional studies (randomized controlled trials, controlled clinical trials, and case series including ≥5 participants) on OLP and oral lichenoid reactions published between January 2001 and March 2022 without language restriction. All reported primary and secondary outcomes were extracted.Results: The searches yielded 9,135 records, and 291 studies were included after applying the inclusion criteria. A total of 422 outcomes were identified. These were then grouped based on semantic similarity, condensing the list to 69 outcomes. The most frequently measured outcomes were pain (51.9%), clinical grading of the lesions (29.6%), lesion size/extension/area (27.5%), and adverse events (17.5%). Conclusion: As a first step in developing a COS for OLP, we summarized the outcomes that have been used in interventional studies over the past 2 decades, which are numerous and heterogeneous.
PB Elsevier
SN 2212-4403
YR 2023
FD 2023
LK http://hdl.handle.net/10347/32745
UL http://hdl.handle.net/10347/32745
LA eng
NO Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Volume 135, Issue 6, June 2023, Pages 772-780. https://doi.org/10.1016/j.oooo.2023.01.014
DS Minerva
RD 24 abr 2026