RT Journal Article
T1 The Shark Basal Hypothalamus: Molecular Prosomeric Subdivisions and Evolutionary Trends
A1 Santos Durán, Gabriel Nicolás
A1 Ferreiro Galve, Susana
A1 Menuet, Arnaud
A1 Mazan, Sylvie
A1 Rodríguez-Moldes Rey, María Isabel
A1 Candal Suárez, Eva María
K1 Chondrichthyan
K1 Basal hypothalamus
K1 Evo-devo
K1 Prosomeric model
K1 Segments
K1 Shh
K1 PCNA
AB The hypothalamus is a key integrative center of the vertebrate brain. To betterunderstand its ancestral morphological organization and evolution, we previouslyanalyzed the segmental organization of alar subdivisions in the catshark Scyliorhinuscanicula, a cartilaginous fish and thus a basal representative of gnathostomes (jawedvertebrates). With the same aim, we deepen here in the segmental organization ofthe catshark basal hypothalamus by revisiting previous data on ScOtp, ScDlx2/5,ScNkx2.1, ScShh expression and Shh immunoreactivity jointly with new data onScLhx5, ScEmx2, ScLmx1b, ScPitx2, ScPitx3a, ScFoxa1, ScFoxa2 and ScNeurog2expression and proliferating cell nuclear antigen (PCNA) immunoreactivity. Our studyreveals a complex genoarchitecture for chondrichthyan basal hypothalamus on whicha total of 21 microdomains were identified. Six belong to the basal acroterminal region,the rostral-most point of the basal neural tube; seven are described in the tuberalregion (Tu/RTu); four in the perimamillar region (PM/PRM) and four in the mamillar one(MM/RM). Interestingly, the same set of genes does not necessarily describe the samemicrodomains in mice, which in part contributes to explain how forebrain diversity isachieved. This study stresses the importance of analyzing data from basal vertebratesto better understand forebrain diversity and hypothalamic evolution.
PB Frontiers Media
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22374
UL http://hdl.handle.net/10347/22374
LA eng
NO Santos-Durán, G. N., Ferreiro-Galve, S., Menuet, A., Mazan, S., Rodríguez-Moldes, I., & Candal, E. (2018). The Shark Basal Hypothalamus: Molecular Prosomeric Subdivisions and Evolutionary Trends. Frontiers in neuroanatomy, 12, 17.
NO This work was supported by grants from the Spanish Dirección General de Investigación-FEDER (BFU2010-15816, BFU2014-58631-P), the Xunta de Galicia (10PXIB200051PR, IN 845B-2010/159, CN 2012/237), and the Région Centre, Région Bretagne (EVOVERT grant number049755)
DS Minerva
RD 29 abr 2026