RT Journal Article
T1 Do informant-reported subjective cognitive complaints predict progression to mild cognitive impairment and dementia better than self-reported complaints in old adults? A meta-analytical study
A1 Pérez Blanco, Lucía
A1 Felpete López, Alba
A1 Patten, Scott B.
A1 Mallo López, Sabela Carme
A1 Pereiro Rozas, Arturo X.
A1 Campos Magdaleno, María
A1 Juncos Rabadán, Onésimo
K1 Self-report
K1 Informant-report
K1 Subjective cognitive decline
K1 Progression
K1 Cognitive impairment
K1 Meta-analysis
AB Background: Subjective cognitive complaints (SCCs) are considered a risk factor for objective cognitive decline and conversion to dementia. The aim of this study was to determine whether self-reported or informant-reported SCCs best predict progression to mild cognitive impairment (MCI) and/or dementia. Methods: We reviewed prospective longitudinal studies of Cognitively Unimpaired (CU) older adults with self-reported and informant-reported SCCs at baseline, assessed by questions or questionnaires that considered the transition to MCI and/or dementia. A random-effects meta-analysis was performed to obtain pooled estimates and 95% CIs. Results: Both self-reported and informant-reported SCCs are associated with an elevated risk of transition from CU to MCI and/or dementia. The association appears stronger and more robust for informant-reported data [1.38, with a 95% CI of 1.16 –1.64, p < 0.001] than for self-reported data [1.27 (95% CI 1.06 – 1.534, p = 0.011].ConclusionsOur results suggest that corroborated information from one informant could provide important details for distinguishing between normal aging and clinical states
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29479
UL http://hdl.handle.net/10347/29479
LA eng
NO Ageing Research Reviews  82 (2022) 101772
NO This work was supported though FEDER founds by the Spanish National Research Agency (Spanish 'Ministry of Science, Innovation and Universities) (Project Ref. PSI2017-89389-C2-1-R), FEDER founds (‘A way to make Europe’) by the Spanish AEI (Doi: 10.13039/501100011033; Refs. PID2020-114521RB-C21 and PSI2017-89389-C2-1-R) and by the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema Universitario de Galicia; GI-1807-USC: Ref. ED431C 2021/04)
DS Minerva
RD 28 abr 2026