RT Journal Article
T1 Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles
A1 López-Blanco, Roi
A1 Fernández Villamarín, Marcos
A1 Jatunov, Sorel
A1 Novoa Carballal, Ramón
A1 Fernandez-Megia, Eduardo
A1 Fernández Megía, Eduardo
K1 Polyion complex micelle
K1 Polysaccharide
K1 Dendrimer
K1 Drug delivery
AB Dendritic-polysaccharide polyion complex (PIC) micelles represent promising delivery systems where dendritic rigidity and polysaccharide stiffness synchronize to determine the stability and compactness of the micelles, their kinetics of intracellular drug release, and cytotoxicity. A screening using three charged polysaccharides (chitosan, alginate, and hyaluronic acid) with varying molecular weights (MWs) confirmed PEG-dendritic block copolymers as privileged structural components for the preparation of otherwise unfeasible PIC micelles from PEG-linear copolymers. The superior stability of dendritic PIC micelles is associated with the intrinsic rigidity and globular nature of dendrimers. Indeed, large differences in local dynamics between linear polymers and dendrimers have been described. Remarkably, lower polydispersity and longer-term micelle stability were revealed on reducing the polysaccharide MW, an effect not previously observed for PIC and associated with the high stiffness of charged polysaccharides. The polysaccharide MW-dependent properties of these micelles were analyzed in detail by encapsulating the fluorescent anticancer drug doxorubicin, which confirmed a higher compactness and slower intracellular drug release of micelles prepared from shorter polysaccharides. Overall, a control of the stability, release properties, and cytotoxicity of PIC micelles that is not attainable with linear polymers is feasible with dendrimers by selecting the MW of an oppositely charged polysaccharide
PB Royal Society of Chemistry
SN 1759-9954
YR 2019
FD 2019-07-23
LK https://hdl.handle.net/10347/45881
UL https://hdl.handle.net/10347/45881
LA eng
NO Lopez-Blanco, R., Fernandez-Villamarin, M., Jatunov, S., Novoa-Carballa, R. Fernandez-Megia, E. (2019). Polysaccharides meet dendrimers to fine-tune the stability and release properties of polyion complex micelles. "Polymer Chemistry", vol. 10, 4709-4717
NO This work was financially supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (CTQ2015-69021-R; RTI2018-102212-B-I00), the Xunta de Galicia (ED431C 2018/30 and Centro Singular de Investigación de Galicia Accreditation 2016-2019, ED431G/09) and the European Union (European Regional Development Fund-ERDF). The authors thank Dr David Gil-Carton for help with cryo-TEM data collection at the EM Platform at CIC bioGUNE (Bilbao, Spain)
DS Minerva
RD 20 may 2026