RT Journal Article
T1 Interaction between angiotensin type 1, type 2, and mas receptors to regulate adult neurogenesis in the brain ventricular–subventricular zone
A1 García Garrote, María
A1 Pérez Villalba, Ana
A1 Garrido Gil, Pablo
A1 Belenguer, Germán
A1 Parga Martín, Juan Andrés
A1 Pérez Sánchez, Francisco
A1 Labandeira García, José Luis
A1 Fariñas, Isabel
A1 Rodríguez Pallares, Jannette
K1 Neural stem cells
K1 Ventricular–subventricular zone
K1 AT1 receptors
K1 AT2 receptors
K1 Aging
K1 Proliferation
K1 Neurospheres
AB The renin–angiotensin system (RAS), and particularly its angiotensin type-2 receptors (AT2), have been classically involved in processes of cell proliferation and maturation during development. However, the potential role of RAS in adult neurogenesis in the ventricular-subventricular zone (V-SVZ) and its aging-related alterations have not been investigated. In the present study, we analyzed the role of major RAS receptors on neurogenesis in the V-SVZ of adult mice and rats. In mice, we showed that the increase in proliferation of cells in this neurogenic niche was induced by activation of AT2 receptors but depended partially on the AT2-dependent antagonism of AT1 receptor expression, which restricted proliferation. Furthermore, we observed a functional dependence of AT2 receptor actions on Mas receptors. In rats, where the levels of the AT1 relative to those of AT2 receptor are much lower, pharmacological inhibition of the AT1 receptor alone was sufficient in increasing AT2 receptor levels and proliferation in the V-SVZ. Our data revealed that interactions between RAS receptors play a major role in the regulation of V-SVZ neurogenesis, particularly in proliferation, generation of neuroblasts, and migration to the olfactory bulb, both in young and aged brains, and suggest potential beneficial effects of RAS modulators on neurogenesis.
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21395
UL http://hdl.handle.net/10347/21395
LA eng
NO Garcia-Garrote, M.; Perez-Villalba, A.; Garrido-Gil, P.; Belenguer, G.; Parga, J.A.; Perez-Sanchez, F.; Labandeira-Garcia, J.L.; Fariñas, I.; Rodriguez-Pallares, J. Interaction between Angiotensin Type 1, Type 2, and Mas Receptors to Regulate Adult Neurogenesis in the Brain Ventricular–Subventricular Zone. Cells 2019, 8, 1551.
NO This research was funded by Spanish grants from Ministerio de Economía y Competitividad (BFU2015-70523 and SAF2017-86690-R), Instituto de Salud Carlos III (Retic TERCEL RD16/0011/0016, RD16/0011/0017, and CIBERNED), Galician Government (XUGA, ED431C2018/10; ED431G/05), FEDER (Regional European Development Fund), Generalitat Valenciana (Prometeo 2017-030), and Fundación Emilio Botín-Banco Santander
DS Minerva
RD 24 abr 2026