RT Journal Article
T1 Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status
A1 Rupérez, Azahara I.
A1 Mesa, María D.
A1 Anguita Ruiz, Augusto
A1 González Gil, Esther M.
A1 Vázquez Cobela, Rocío
A1 Moreno, Luis A.
A1 Gil, Ángel
A1 Gil Campos, Mercedes
A1 Leis Trabazo, María Rosaura
A1 Bueno Lozano, Gloria
A1 Aguilera, Concepción M.
K1 Carotenoids
K1 Tocopherols
K1 Oxidized low-density lipoprotein
K1 Inflammatory biomarkers
K1 Childhood obesity
K1 Metabolically healthy
K1 Metabolic syndrome
AB Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23858
UL http://hdl.handle.net/10347/23858
LA eng
NO Rupérez, A.I.; Mesa, M.D.; Anguita-Ruiz, A.; González-Gil, E.M.; Vázquez-Cobela, R.; Moreno, L.A.; Gil, Á.; Gil-Campos, M.; Leis, R.; Bueno, G.; Aguilera, C.M. Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status. Antioxidants 2020, 9, 618
NO This research was supported by the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI051968, PI11/01425, PI1102042, PI11/02059, PI16/01301, PI16/012 and PI1600871); CIBEROBN Network (CB12/03/30038, CB15/00131, CB15/00043). The authors also acknowledge the University of Granada ‘Plan Propio de Investigacion 2016-Excellence actions: Unit of Excellence on Exercise and Health (UCEES)’
DS Minerva
RD 24 abr 2026