RT Journal Article
T1 Does the Animal Model Influence in Vertical Alveolar Distraction? A Systematic Review of the Literature
A1 García González, Mario
A1 Muñoz Guzón, Fernando María
A1 González Cantalapiedra, Antonio
A1 López Peña, Mónica
A1 Saulacic, Nikola
K1 Animal model
K1 Animal experimentation
K1 Distraction osteogenesis
K1 Biomaterials
K1 Alveolar ridge augmentation
K1 VAOD
K1 Systematic review
AB This study is aimed at synthesizing all available evidence on vertical alveolar osteogenesis distraction (VAOD) in animal trials to determine whether the animal model used and its handling influence or not, and find which is the most appropriate animal model for this specific technique. This systematic review has been carried out following the PRISMA statements. Bibliographic sources have been consulted manually by two reviewers. Risk of bias was assessed using a version of the Newcastle-Ottawa-Scale (NOS). The selection criteria established by expert researchers were applied in order to decide which studies should be included in the review. Twenty-six studies met the inclusion criteria and were included in the review. Twenty-four of them had a high quality (score between 7 and 9), two medium quality (score between 4 and 6), and none low quality (score between 1 and 3). The highest possible score was 9 (using the NOS). Six studies complied with all NOS criteria. The animal model has been seen to influence the results, leading to failure in some cases. The most used animal model on VAOD, with fewer complications, was the Mongrel dog. The use of the pig and minipig is not recommended, due to the difficulties in handling and complications encountered
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23993
UL http://hdl.handle.net/10347/23993
LA eng
NO García-González, M.; Muñoz, F.; González-Cantalapiedra, A.; López-Peña, M.; Saulacic, N. Does the Animal Model Influence in Vertical Alveolar Distraction? A Systematic Review of the Literature. Animals 2020, 10, 2347
DS Minerva
RD 23 abr 2026