RT Journal Article
T1 Drug testing in biological samples vs. maternal surveys for the detection of substance use during whole pregnancy
A1 González-Colmenero, Eva
A1 Concheiro Guisán, Ana
A1 Lorenzo-Martínez, Marta
A1 Concheiro, Marta
A1 Lendoiro Belío, Elena
A1 Castro Ríos, Ana de
A1 Cañizo-Vázquez. Débora, 
A1 Martínez-Reglero, Cristina
A1 Fernández Lorenzo, José Ramón
K1 Drug; intrauterine exposure; meconium; newborn; placenta.
AB Background: Early diagnosis of nicotine, ethanol and drug use during pregnancy is critical in order to provide adequate care. Current screening procedures show limitations in terms of reliability and short windows of detection.Objectives: To investigate the prevalence and identify biomarkers of substance use and changes in substance use during pregnancy. To compare drug testing results in different types of biological samples (maternal hair, meconium, placenta, umbilical-cord) with self-reported data.Participants and setting: Prospective cohort study using data from pregnant women and their newborns.Methods: Biological matrices were collected at birth and analyzed by liquid chromatography tandem mass spectrometry. A paper survey was provided to determine substance use habits.Results: 867 mother-newborn pairs were included. According to the analysis of biological samples, 29.1% cases were positive for one or more substances (13.6% nicotine, 8.4% ethanol, 8.3% cocaine, 6.4% cannabis, 5.7% opioids). The profile of the substance-using mother was a single woman, <28 years-old, with no higher education and unemployed. Segmental maternal hair analysis showed a decrease in tobacco, cannabis and cocaine use throughout pregnancy (p < 0.001). The level of concordance between results from interviews and from biological analyses was weak for opioids, cocaine, and cannabis (kappa coefficient < 0.40). Maternal hair detected the highest number of cases, followed by meconium and by placenta and/or umbilical-cord.Conclusions: Maternal survey was not a reliable screening technique. Analysis of maternal hair detected the highest number of cases with the broadest detection window (whole pregnancy).
PB Taylor and Francis
YR 2020
FD 2020-10-12
LK https://hdl.handle.net/10347/38646
UL https://hdl.handle.net/10347/38646
LA eng
NO González-Colmenero E, Concheiro-Guisán A, Lorenzo-Martínez M, Concheiro M, Lendoiro E, de-Castro-Ríos A, Cañizo-Vázquez D, Martínez-Reglero C, Fernández-Lorenzo JR. Drug testing in biological samples vs. maternal surveys for the detection of substance use during whole pregnancy. J Addict Dis. 2021 Apr-Jun;39(2):175-182. doi: 10.1080/10550887.2020.1831137. Epub 2020 Oct 12. PMID: 33043834.
DS Minerva
RD 27 abr 2026