RT Journal Article
T1 Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice
A1 Pazos Mendoza, Patricia
A1 Lima Rodríguez, Luis
A1 Tovar Carro, Sulay A.
A1 González Touceda, David
A1 Diéguez González, Carlos
A1 García García, María del Carmen
K1 Energy metabolism
K1 Fat metabolism
K1 Feeding behaviour
K1 Homeostasis
AB Brown and beige adipocytes recruitment in brown (BAT) or white adipose tissue, mainly in the inguinal fat pad (iWAT), meet the need for temperature adaptation in cold-exposure conditions and protect against obesity in face of hypercaloric diets. Using interleukin18 (Il18) and Il18 receptor 1- knockout (Il18r1-KO) mice, this study aimed to investigate the role of IL18 signaling in BAT and iWAT activation and thermogenesis under both stimuli. Il18-KO, extremely dietary obesity-prone as previously described, failed to develop diet-induced thermogenesis as assessed by BAT and iWAT Ucp1 mRNA levels. Overweight when fed standard chow but not HFD, HFD-fed Il18r1-KO mice exhibited increased iWAT Ucp1 gene expression. Energy expenditure was reduced in pre-obese Il18r1-KO mice and restored upon HFD-challenge. Cold exposure lead to similar results; Il18r1-KO mice were protected against acute body temperature drop, displaying a more brown-like structure, alternative macrophage activation and thermogenic gene expression in iWAT than WT controls. Opposite effects were observed in Il18-KO mice. Thus, Il18 and Il18r1 genetic ablation disparate effects on energy homeostasis are likely mediated by divergent BAT responses to thermogenic stimuli as well as iWAT browning. These results suggest that a more complex receptor-signaling system mediates the IL18 adipose-tissue specific effects in energy expenditure.
PB Nature Publishing Group
YR 2015
FD 2015
LK http://hdl.handle.net/10347/23054
UL http://hdl.handle.net/10347/23054
LA eng
NO Pazos, P., Lima, L., Tovar, S. et al. Divergent responses to thermogenic stimuli in BAT and subcutaneous adipose tissue from interleukin 18 and interleukin 18 receptor 1-deficient mice. Sci Rep 5, 17977 (2016). https://doi.org/10.1038/srep17977
NO This work has been supported by European Community (FP7/2007n° 245009: “NeuroFAST”), Ministerio de Economía y Competitividad (PP and MCGG: BFU2007–62683/BFI and PP, MCGG and CD: CIBERobn (CB06/03)) and Xunta de Galicia Grants (MCGG and LL: PGIDIT06PXIB208067PR and GPC2014/030). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII
DS Minerva
RD 28 abr 2026