RT Journal Article
T1 How to explain the beneficial effects of leukocyte‐ and platelet‐rich fibrin
A1 Blanco Carrión, Juan
A1 García Alonso, Ángel
A1 Hermida Nogueira, Lidia
A1 Castro, Ana B.
K1 Analgesic
K1 Antibacterial
K1 Antimicrobial
K1 Bone healing
K1 Bone regeneration
K1 Hemostatic
K1 Leukocyte- and platelet-rich fibrin
K1 Pain
K1 Soft tissue regeneration
K1 Wound healing
AB The survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents, and inflammation. This process involving cell proliferation and differentiation is driven by several growth factors and is critically dependent on the organization of the extracellular matrix. Since autologous platelet concentrates (APCs) are fibrin matrices in which cells, growth factors, and cytokines are trapped and delivered over time, they are able to influence that response at different levels. The present review thoroughly describes the molecular components present in one of these APCs, leukocyte- and platelet-rich fibrin (L-PRF), and summarizes the level of evidence regarding the influence of L-PRF on anti-inflammatory reactions, analgesia, hemostasis, antimicrobial capacity, and its biological mechanisms on bone/soft tissue regeneration.
PB Wiley
SN 0906-6713
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34980
UL http://hdl.handle.net/10347/34980
LA eng
NO Blanco J, García Alonso A, Hermida-Nogueira L, Castro A. How to explain the beneficial effects of leucocyte- and platelet-rich fibrin. Periodontology 2000. 2024; 00: 1-21. doi:10.1111/prd.12570
DS Minerva
RD 27 abr 2026