RT Journal Article
T1 C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions
A1 Alende-Castro, V.
A1 Alonso Sampedro, Manuela
A1 Fernández-Merino, Carmen
A1 Sánchez-Castro, Juan José
A1 Sopeña Pérez-Argüelles, Bernardo
A1 Gude Sampedro, Francisco
A1 González Quintela, Arturo
K1 Age
K1 Alcohol
K1 Body Mass Index
K1 C-Reactive Protein
K1 Erythrocyte Sedimentation Rate
K1 Inflammatory Disorders
K1 Interleukin-6
K1 Metabolic Syndrome
K1 Obesity
K1 Physical Exercise
K1 Sex
K1 Smoking
AB Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.Methods: We conducted a cross-sectional study of 1472 adults with no known inflammatory disorders (44.5% male; median age, 52 years; range, 18-91 years), randomly selected from a municipality in Spain. The participants underwent simultaneous measurements of ESR, serum CRP, and interleukin-6 concentrations. Alcohol consumption, smoking, and physical activity were evaluated by questionnaire. Body mass index (BMI) measurement and metabolic syndrome criteria were available for all participants.Results: Most (n = 1123, 74.9%) of the participants showed normal CRP and ESR values. Sixty-nine (4.6%) participants showed high CRP and ESR values. Seventy-two (4.8%) participants showed a discordant pattern of high ESR and normal CRP values, which was associated with age after adjusting for sex, alcohol consumption, physical activity, BMI, and the presence of metabolic syndrome (odds ratio [OR], 1.052; 95% CI, 1.034-1.071; P < .001). A total of 208 (13.8%) participants showed a discordant pattern of high CRP and normal ESR values, which was associated with BMI after adjusting for covariates (OR, 1.099; 95% CI, 1.064-1.136; P < .001). BMI appeared to be the main determinant of serum CRP concentrations in this population. Serum interleukin-6 concentrations were positively associated with the discordant pattern of high CRP and normal ESR values.Conclusion: In this general adult population with no overt inflammatory disease, the discordant pattern of high ESR and normal CRP was associated with greater age, whereas the pattern of high CRP and normal ESR was associated with higher BMI.
PB American Board Family Medicine (High Wire)
YR 2021
FD 2021-09-28
LK https://hdl.handle.net/10347/45428
UL https://hdl.handle.net/10347/45428
LA eng
NO Alende-Castro V, Alonso-Sampedro M, Fernández-Merino C, Sánchez-Castro J, Sopeña B, Gude F, Gonzalez-Quintela A. C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions. J Am Board Fam Med. 2021 Sep-Oct;34(5):974-983. doi: 10.3122/jabfm.2021.05.210072. PMID: 34535522.
NO The study was supported by a grant from the Carlos III Institute of Health (Instituto de Salud Carlos III, PI16/01404 and PI16/01395), the Spanish Network for Additive Disorders (Red de Trastornos Adictivos, RD16/ 0017/0018, Spanish Ministry of Health) the Spanish Network for Preventive Activity and Health Promotion Research in Primary Care (Red de Actividades Preventivas y de Promocion de Salud en Atención Primaria, RD16/0007/0006), and the European Regional Development Fund (FEDER).
DS Minerva
RD 24 abr 2026