RT Journal Article
T1 Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance
A1 López Vilaret, Karel Mauricio
A1 Cantero Lorente, José Luis
A1 Fernández Álvarez, Marina
A1 Calero Lara, Miguel
A1 Calero Rueda, Olga
A1 Lindín Novo, Mónica
A1 Zurrón Ocio, Montserrat
A1 Díaz Fernández, Fernando
A1 Atienza, Mercedes
K1 Adiponectin
K1 Leptin
K1 Cognitive function
K1 Cortical thickness
K1 Metabolism
AB Evidence suggests that aging-related dysfunctions of adipose tissue and metabolic disturbances increase the risk of diabetes and metabolic syndrome (MtbS), eventually leading to cognitive impairment and dementia. However, the neuroprotective role of adipocytokines in this process has not been specifically investigated. The present study aims to identify metabolic alterations that may prevent adipocytokines from exerting their neuroprotective action in normal ageing. We hypothesize that neuroprotection may occur under insulin resistance (IR) conditions as long as there are no other metabolic alterations that indirectly impair the action of adipocytokines, such as hyperglycemia. This hypothesis was tested in 239 cognitively normal older adults (149 females) aged 52 to 87 years (67.4 ± 5.9 yr). We assessed whether the homeostasis model assessment-estimated insulin resistance (HOMA-IR) and the presence of different components of MtbS moderated the association of plasma adipocytokines (i.e., adiponectin, leptin and the adiponectin to leptin [Ad/L] ratio) with cognitive functioning and cortical thickness. The results showed that HOMA-IR, circulating triglyceride and glucose levels moderated the neuroprotective effect of adipocytokines. In particular, elevated triglyceride levels reduced the beneficial effect of Ad/L ratio on cognitive functioning in insulin-sensitive individuals; whereas under high IR conditions, it was elevated glucose levels that weakened the association of the Ad/L ratio with cognitive functioning and with cortical thickness of prefrontal regions. Taken together, these findings suggest that the neuroprotective action of adipocytokines is conditioned not only by whether cognitively normal older adults are insulin-sensitive or not, but also by the circulating levels of triglycerides and glucose, respectively
PB Impact Journals
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27494
UL http://hdl.handle.net/10347/27494
LA eng
NO Lopez-Vilaret KM, Cantero JL, Fernandez-Alvarez M, Calero M, Calero O, Lindín M, Zurrón M, Díaz F, Atienza M. Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance. Aging (Albany NY). 2021; 13:23936-23952
NO This work was supported by the Spanish Ministry of Economy and Competitiveness (PSI2017-85311-P to M.A., PSI2017-89389-C2-2-R to F.D., PID2020-118825GB-I00 to M.A., PID2020-119978RB-I00 to J.L.C.), CIBERNED (CB06/05/1111 to J.L.C.), the International Center on Aging CENIE-POCTEP (0348_CIE_6_E to M.A.), the Research Program for a Long-Life Society (0551_PSL_6_E to J.L.C.), the Junta de Andalucía (PY20_00858 to J.L.C.), the Andalucía-FEDER Program (UPO-1380913 to J.L.C.), and the Galician Government (ED431-2017/27 to F.D.) with ERDF/FEDER funds
DS Minerva
RD 24 abr 2026