RT Journal Article
T1 Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines
A1 Álvarez Pérez, Andrea
A1 González Rodríguez, Carlos
A1 García Yebra, Cristina
A1 Varela Carrete, Jesús Ángel
A1 Oñate Rodríguez, Enrique
A1 Esteruelas Rodrigo, Miguel Ángel
A1 Saá Rodríguez, Carlos
K1 Benzazepines
K1 Cyclization
K1 Metallacyclopropenes
K1 Osmium catalysts
K1 Phenethylamines
AB A novel osmium‐catalyzed cyclization of o‐alkynyl phenethylamines to give 3‐benzazepines is reported. The procedure allows the straightforward preparation of a broad range of dopaminergic 3‐benzazepine derivatives. Mechanistic investigations revealed that the process takes place via osmacyclopropene intermediates, which were isolated and characterized by X‐ray crystallography.
PB Wiley
SN 1433-7851
YR 2015
FD 2015
LK http://hdl.handle.net/10347/23347
UL http://hdl.handle.net/10347/23347
LA eng
NO Álvarez-Pérez, A., González-Rodríguez, C., García-Yebra, C., Varela, J. A., Oñate, E., Esteruelas, M. A., Saá, C. (2015). Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines. Angew. Chem. Int. Ed., 54, 45, 13357-13361
NO NOTICE: This is the peer reviewed version of the following article: Álvarez-Pérez, A., González-Rodríguez, C., García-Yebra, C., Varela, J. A., Oñate, E., Esteruelas, M. A., Saá, C. (2015). Catalytic Cyclization of o‐Alkynyl Phenethylamines via Osmacyclopropene Intermediates: Direct Access to Dopaminergic 3‐Benzazepines. Angew. Chem. Int. Ed., 54, 45, 13357-13361. [doi: 10.1002/anie.201505782]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving
NO This work was supported by MICINN (projects CTQ2011-28258, CTQ2014-52799-P, and CTQ2014-51912REDC), Xunta de Galicia and European Regional Development Fund (projects GRC2014/032 and EM 2012/051), the DGA (E-35) and the European Social Fund (SFE). A. A.-P. and C. G.-R. thank Spanish MICINN for a predoctoral FPI fellowship and Juan de la Cierva Contract (JCI-2011-09946), respectively
DS Minerva
RD 23 abr 2026