RT Journal Article
T1 Detection of Genomic Regions with Pleiotropic Effects for Growth and Carcass Quality Traits in the Rubia Gallega Cattle Breed
A1 Then Rodríguez, Carlos Mirokys
A1 Altarriba Farrán, Juan
A1 Srihi, Houssemeddine
A1 López Carbonell, David
A1 Martínez Portela, Paulino
A1 Hermida, Miguel
A1 Varona, Luis
A1 Martínez Castillero, María
A1 Díaz, Clara
K1 SNP
K1 GWAS
K1 Beef cattle
K1 Single-step GBLUP
K1 Candidate genes
K1 Pleiotropy
AB The breeding scheme in the Rubia Gallega cattle population is based upon traits measured in farms and slaughterhouses. In recent years, genomic evaluation has been implemented by using a ssGBLUP (single-step Genomic Best Linear Unbiased Prediction). This procedure can reparameterized to perform ssGWAS (single-step Genome Wide Association Studies) by backsolving the SNP (single nucleotide polymorphisms) effects. Therefore, the objective of this study was to identify genomic regions associated with the genetic variability in growth and carcass quality traits. We implemented a ssGBLUP by using a database that included records for Birth Weight (BW-327,350 records-), Weaning Weight (WW-83,818-), Cold Carcass Weight (CCW-91,621-), Fatness (FAT-91,475-) and Conformation (CON-91,609-). The pedigree included 464,373 individuals, 2449 of which were genotyped. After a process of filtering, we ended up using 43,211 SNP markers. We used the GBLUP and SNPBLUP model equivalences to obtain the effects of the SNPs and then calculated the percentage of variance explained by the regions of the genome between 1 Mb. We identified 7 regions of the genome for CCW; 8 regions for BW, WW, FAT and 9 regions for CON, which explained the percentage of variance above 0.5%. Furthermore, a number of the genome regions had pleiotropic effects, located at: BTA1 (131–132 Mb), BTA2 (1–11 Mb), BTA3 (32–33 Mb), BTA6 (36–38 Mb), BTA16 (24–26 Mb), and BTA 21 (56–57 Mb). These regions contain, amongst others, the following candidate genes: NCK1, MSTN, KCNA3, LCORL, NCAPG, and RIN3.
PB MDPI
SN 2076-2615
YR 2021
FD 2021-06-04
LK http://hdl.handle.net/10347/32012
UL http://hdl.handle.net/10347/32012
LA eng
NO Martinez-Castillero, M.; Then, C.; Altarriba, J.; Srihi, H.; López-Carbonell, D.; Díaz, C.; Martinez, P.; Hermida, M.; Varona, L. Detection of Genomic Regions with Pleiotropic Effects for Growth and Carcass Quality Traits in the Rubia Gallega Cattle Breed. Animals 2021, 11, 1682. https://doi.org/10.3390/ani11061682
NO This research was funded by FEADER, grant number 2019/053A.
DS Minerva
RD 24 abr 2026