RT Journal Article
T1 Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys
A1 Fernández López, Blanca
A1 Romaus-Sanjurjo, Daniel
A1 Cornide Petronio, María Eugenia
A1 Gómez Fernández, Sonia
A1 Barreiro Iglesias, Antón
A1 Rodicio Rodicio, María Celina
AB Following a spinal injury, lampreys at first are paralyzed below the level of transection. However, they recover locomotion after several weeks, and this is accompanied by the regeneration of descending axons from the brain and the production of new neurons in the spinal cord. Here, we aimed to analyse the changes in the dopaminergic system of the sea lamprey after a complete spinal transection by studying the changes in dopaminergic cell numbers and dopaminergic innervation in the spinal cord. Changes in the expression of the D2 receptor were also studied. We report the full anatomical regeneration of the dopaminergic system after an initial decrease in the number of dopaminergic cells and fibres. Numbers of dopaminergic cells were recovered rostrally and caudally to the site of injury. Quantification of dopaminergic profiles revealed the full recovery of the dopaminergic innervation of the spinal cord rostral and caudal to the site of injury. Interestingly, no changes in the expression of the D2 receptor were observed at time points in which a reduced dopaminergic innervation of the spinal cord was observed. Our observations reveal that in lampreys a spinal cord injury is followed by the full anatomical recovery of the dopaminergic system.
PB Hindawi
SN 2090-5904
YR 2015
FD 2015
LK http://hdl.handle.net/10347/22825
UL http://hdl.handle.net/10347/22825
LA eng
NO Fernández-López, B., Romaus-Sanjurjo, D., Cornide-Petronio, M. E., Gómez-Fernández, S., Barreiro-Iglesias, A., & Rodicio, M. C. (2015). Full Anatomical Recovery of the Dopaminergic System after a Complete Spinal Cord Injury in Lampreys. Neural Plasticity, 2015, 1-10. https://doi.org/10.1155/2015/350750
NO This work was funded by the Spanish Ministry of Science and Innovation, Grant no. BFU2010–17174, to María Celina Rodicio. Sonia Gómez-Fernández and Antón Barreiro-Iglesias were supported by predoctoral and postdoctoral grants, respectively, from the Xunta de Galicia (Galicia, Spain)
DS Minerva
RD 23 abr 2026