RT Journal Article
T1 Bioaccumulation and human risk assessment of inorganic nanoparticles in aquaculture species
A1 Suárez-Oubiña, Cristian
A1 Herbello-Hermelo, Paloma
A1 Mallo, Natalia
A1 Vázquez, María
A1 Cabaleiro, Santiago
A1 Domínguez González, Raquel
A1 Moreda Piñeiro, Antonio
A1 Bermejo Barrera, Pilar
AB The escalating use of inorganic nanoparticles (NPs) in various applications raises concerns regarding their potential environmental release and subsequent bioaccumulation in the food chain, posing a risk to human health. This study aimed to assess the bioaccumulation potential of titanium dioxide (TiO2) and silver (Ag) NPs in three commercially relevant aquatic species: sea bream, sea bass, and Japanese carpet shell, and evaluate the associated human health risks through dietary exposure. Bioaccumulation patterns were evaluated in target organs (liver, kidney, and muscle) of sea bream and sea bass following dietary exposure to varying concentrations of NPs (0.25–1.5 mg kg−1) for extended durations (up to 90 days). While moderate bioaccumulation was observed in non-edible organs like kidneys and livers, no significant accumulation was detected in the muscle tissue, even at high exposure levels. Conversely, bioaccumulation of both TiO2 and Ag NPs was evident in the soft tissues of Japanese carpet shell (maximum concentrations: 2.5 × 1010 g−1 for Ag NPs and 8.0 × 106 g−1 for TiO2 NPs). In vitro studies utilizing the Caco-2 human intestinal model revealed limited transcellular transport of NPs from both fish and shellfish muscle tissue (less than 34% for TiO2 NPs in sea bream and less than 61% and 4% for TiO2 NPs and Ag NPs, respectively, in Japanese carpet shell). These findings suggest that, while bioaccumulation may occur in certain species and organs, the human health risk associated with dietary exposure to NPs from commonly consumed fish appears to be low due to limited intestinal uptake. However, further research is necessary to elucidate the long-term consequences of chronic exposure and potential health effects.
PB Royal Society of Chemistry
SN 2051-8153
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34613
UL http://hdl.handle.net/10347/34613
LA eng
NO Environ. Sci.: Nano, 2024,11, 2937-2947
NO Authors thank funding from Interreg (10.1339/100013276) ACUINANO, reference 07-12-ACUINANO_1_E; Agencia Estatal de Investigación (10.13039/501100011033) FOODNANORISK, reference PID2021-125276NB-I00); and Conselleria de Cultura, Educación e Ordenación Universitaria Xunta de Galicia (10.13039/501100008425) Grupo de Referencia Competitiva, reference ED431C 2022/029.
DS Minerva
RD 23 abr 2026