RT Journal Article
T1 Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(III) and Eu(III) ions for specific sensing of a viral RNA
A1 Penas Tallón, Cristina
A1 Mascareñas Cid, José Luis
A1 Vázquez Sentís, Marco Eugenio
AB Rational modification of a natural RNA-binding peptide with a lanthanide EDTA chelator, and a phenanthroline ligand yields a highly selective luminescent sensor. The sensing mechanism relies on the RNA-triggered folding of the peptide into a β-hairpin, which promotes the coordination of the phenanthroline sensitizer, and the efficient sensitization of complexed lanthanide ions
PB Royal Society of Chemistry
YR 2016
FD 2016-01-10
LK http://hdl.handle.net/10347/15963
UL http://hdl.handle.net/10347/15963
LA eng
NO PENAS, CRISTINA, MASCAREÑAS, JOSÉ L. and VÁZQUEZ, M. EUGENIO, 2016, Coupling the folding of a β-hairpin with chelation-enhanced luminescence of Tb(iii) and Eu(iii) ions for specific sensing of a viral RNA. Chem. Sci.. 2016. Vol. 7, no. 4, p. 2674-2678. DOI 10.1039/c5sc04501k. Royal Society of Chemistry (RSC)
NO We are thankful for the support given by the Spanish grants SAF2013-41943-R, CTQ2012-31341, and CTQ2013-49317-EXP, the Xunta de Galicia GRC2013-041, the ERDF, and the European Research Council (Advanced Grant No. 340055). Support ofCOST Action CM1105, and of the orfeo-cinqa network are kindly acknowledged. C. P. thanks the Spanish MCINN for her PhD fellowship. We would also like to thank Dr Jos´e R. Couceiro (USC) for his help with the RNA transfection experiments
DS Minerva
RD 24 abr 2026