RT Dissertation/Thesis
T1 Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
A1 Fradera Gelabert, Sara
K1 amorphous solid dispersions
K1 fluid bed
K1 Quality by Design (QbD)
K1 pharmacokinetic
AB In the present thesis, it is demonstrated the potential of fluidbed top-spray technology as an alternative to spray drying forthe production of amorphous solid dispersions (ASDs) intendedfor immediate drug release systems, i.e. tablets.Comparative analysis of ASDs physical properties, stability, anddissolution profiles obtained via both technologies wereconducted. The effect of formulation variables, using fluid bed,was evaluated guided by a Quality by Design (QbD)approach. Finally, three ASD-based prototypes produced usingfluid bed top-spray and different polymeric carriers(HPMCAS-MG and HPMCP HP-55) were developed followed byan in vivo pilot bioavailability study comparing theirpharmacokinetic behaviour with a marketed spray driedformulation.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34496
UL http://hdl.handle.net/10347/34496
LA eng
DS Minerva
RD 22 abr 2026