RT Journal Article
T1 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method
A1 Robles Martínez, Pamela
A1 Xu, Xiaoyan
A1 Trenfield, Sarah J.
A1 Awad, Atheer
A1 Goyanes Goyanes, Álvaro
A1 Telford, Richard
A1 Basit, Abdul W.
A1 Gaisford, Simon
K1 Three-dimensional printing
K1 Additive manufacturing
K1 Printlets
K1 Tablets
K1 Personalized medicines
K1 Multiple-layer dosage forms
K1 Stereolithography
K1 Vat polymerisation
AB Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, caffeine, naproxen, chloramphenicol, prednisolone and aspirin, were printed with different geometries and material compositions. Drug distribution was visualised using Raman microscopy, which showed that whilst separate layers were successfully printed, several of the drugs diffused across the layers depending on their amorphous or crystalline phase. The printed constructs demonstrated excellent physical properties and the different material inclusions enabled distinct drug release profiles of the six actives within dissolution tests. For the first time, this paper demonstrates the feasibility of SLA printing as an innovative platform for multi-drug therapy production, facilitating a new era of personalised polypills
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21335
UL http://hdl.handle.net/10347/21335
LA eng
NO Robles-Martinez, P.; Xu, X.; Trenfield, S.J.; Awad, A.; Goyanes, A.; Telford, R.; Basit, A.W.; Gaisford, S. 3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method. Pharmaceutics 2019, 11, 274
NO The authors thank the Engineering and Physical Sciences Research Council (EPSRC), UK for their financial support (EP/L01646X)
DS Minerva
RD 28 abr 2026