RT Journal Article
T1 Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects
A1 Rouco Méndez, Lara
A1 Alvariño Romero, Rebeca
A1 Alfonso Rancaño, María Amparo
A1 Fernández-Fariña, Sandra
A1 González Noya, Ana María
A1 Martínez Calvo, Miguel
A1 Pedrido Castiñeiras, Rosa
A1 Rodríguez Silva, Laura
A1 Maneiro Maneiro, Marcelino
K1 Reactive Oxygen Species (ROS)
K1 Oxidative stress
K1 Catalytic antioxidants
K1 Superoxide dismutase
K1 Catalase
K1 Neuroprotection
K1 Manganese
K1 Schiff bases
AB Manganosalen complexes are a class of catalytic antioxidants with beneficial effects against different neurological disorders according to various in vitro and in vivo studies. The interest in the factors that determine their antioxidant activity is based on the fact that they are key to achieving more efficient models. In this work, we report a set of new manganosalen complexes, thoroughly characterized in the solid state and in solution by different techniques. The chelating Schiff base ligands used were prepared from condensation of different substituted hydroxybenzaldehydes with 1,2-diaminoethane and 1,3-diaminopropane. The antioxidant activity of the new models was tested through superoxide dismutase and catalase probes in conjunction with the studies about their neuroprotective effects in human SH-SY5Y neuroblastoma cells in an oxidative stress model. The ability to scavenge excess reactive oxygen species (ROS) varied depending on the manganosalen models, which also yielded different improvements in cell survival. An assessment of the different factors that affect the oxidant activity for these complexes, and others previously reported, revealed the major influence of the structural factors versus the redox properties of the manganosalen complexes.
PB MDPI
SN 2076-3921
YR 2024
FD 2024-02-22
LK https://hdl.handle.net/10347/46535
UL https://hdl.handle.net/10347/46535
LA eng
NO Rouco, L., Alvariño, R., Alfonso, A., Fernández-Fariña, S., González-Noya, A. M., Martínez-Calvo, M., Pedrido, R., Rodríguez-Silva, L., & Maneiro, M. (2024). Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects. Antioxidants, 13(3), 265. https://doi.org/10.3390/antiox13030265
NO The research leading to these results has received funding from the following FEDER cofunded grants: from Campus Terra (USC), BreveRiesgo (2022-PU011), CLIMIGAL (2022-PU016); from Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, GRC GI-1682 (ED431C 2021/01), GRC GI-1584 (ED431C 2023/02), MetalBIO Network (ED431D 2017/01); from Ministerio de Ciencia e Innovación IISCIII/PI19/001248, PID 2020-11262RB-C21, PID2021-127531NB-I00 (AEI/10.13039/501100011033/FEDER, UE), Grant CPP2021-008447 funded by MCIN/AEI/10.13039/ 501100011033 and by the European Union NextGenerationEU/PRT; from European Union, Interreg EAPA-0032/2022—BEAP-MAR, HORIZON-MSCA-2022-DN-01-MSCA Doctoral Networks 2022 101119901-BIOTOXDoc and HORIZON-CL6-2023-CIRCBIO-01 COMBO-101135438.
DS Minerva
RD 21 may 2026