RT Dissertation/Thesis
T1 Determining parameters of the Obestatin/GPR39 system action in the peripheral nervous system
A1 Sánchez Temprano, Agustín
K1 Nerve regeneration
K1 Obestatin signalling
K1 Schwaan cell
AB Peripheral nerve injury is a high-incidence clinical problem, significantly affecting the patient’s life quality and causing an enormous socioeconomic burden. It still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory. Accordingly, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. In this scenario, the present study involves the obestatin/GPR39 system in the improvement of the peripheral nerve repair, by enhancing both neuroprotection and remyelination, and thus the regeneration of the damaged nerve, counteracting the severe loss of function and the atrophy of the innervated muscle. Consequently, obestatin is postulated as a potential therapeutic agent for peripheral nervous system regeneration.
YR 2019
FD 2019
LK http://hdl.handle.net/10347/18669
UL http://hdl.handle.net/10347/18669
LA eng
DS Minerva
RD 28 abr 2026