RT Journal Article
T1 Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes
A1 Facal Mayo, David
A1 Guàrdia Olmos, Joan
A1 Pereiro Rozas, Arturo X.
A1 Lojo Seoane, Cristina
A1 Peró Cebollero, Maribel
A1 Juncos Rabadán, Onésimo
K1 Cognitive aging
K1 Mild cognitive impairment
K1 Subjective cognitive complaints
K1 Conversion to dementia
K1 Bayesian odds ratios
K1 Time overlapping intervals
K1 Screening and diagnosis
AB (1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9–15 months—sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27–33—sda-MCI OR = 16 and mda-MCI = 5.06; interval 42–48—sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45–51—sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21101
UL http://hdl.handle.net/10347/21101
LA eng
NO Facal, D.; Guàrdia-Olmos, J.; Pereiro, A.X.; Lojo-Seoane, C.; Peró, M.; Juncos-Rabadán, O. Using an Overlapping Time Interval Strategy to Study Diagnostic Instability in Mild Cognitive Impairment Subtypes. Brain Sci. 2019, 9, 242
NO This work was financially supported through FEDER founds by the Spanish Directorate General of Scientific and Technical Research (Project Ref. PSI2014-55316-C3-1-R), the National Research Agency (Spanish ’Ministry of Science, Innovation and Universities) (Project Ref. PSI2017-89389-C2-1-R) and by the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e estruturación de unidades de investigación competitivas do Sistema Universitario de Galicia; GI-1807-USC: Ref. ED431-2017/27)
DS Minerva
RD 30 abr 2026