RT Journal Article
T1 Analytical methodology for unveiling human exposure to (micro)plastic additives
A1 Estévez-Danta, Andrea
A1 López Vázquez, Javier
A1 Montes Goyanes, Rosa
A1 Quintana Álvarez, José Benito
A1 Rodil Rodríguez, María del Rosario
A1 Zuloaga Zubieta, Olatz
K1 Plastic additives
K1 Bioaccesibility
K1 Human metabolism
K1 Biomonitoring
K1 Wastewater-based epidemiology
AB This review describes a wide variety of analytical approaches for the assessment of human exposure to organic chemicals associated with plastic additives, focusing on works published in the last decade on plasticizers, bisphenols, flame retardants and antioxidants. Physiologically based extraction tests serve as preliminary in-vitro assays to determine the bioaccessibility of these compounds from micro/nanoplastics in body fluids of the gastrointestinal tract, skin, or lung. Whenever plastic-laden compounds become bioavailable, human metabolism is to be monitored through the assessment of phase I and II metabolites. In this regard, analytical methods based on chromatography and mass spectrometry for human biomonitoring of parent compounds and their metabolites in biological samples (mostly urine and plasma) are discussed in depth. This review also covers the role of wastewater-based epidemiology in determining the overall human exposure of a given population to plastic-related species.
PB Elsevier
YR 2024
FD 2024-03-21
LK http://hdl.handle.net/10347/33390
UL http://hdl.handle.net/10347/33390
LA eng
NO A. Estévez-Danta et al. Analytical methodology for unveiling human exposure to (micro)plastic additives. Trends in Analytical Chemistry 173 (2024) 117653
NO The authors thank the Spanish Ministry of Science, Innovation and Universities (MICIU) and the Spanish Research Agency (AEI/10.13039/501100011033) through the AQUASOMIC project (PID2020-117686RB-C31; PID2020-117686RB-C32; PID2020-117686RB-C33), the MICIU, the AEI and the EU through the REefVOLUTION (TED2021-131303B–I00/MICIU/AEI/NextGenerationEU/PRTR) project, the Xunta de Galicia government (ED431C 2021/06) and the Basque Government through the Consolidated Research Group Grant (IT1446-22). Juan F. Ayala-Cabrera acknowledges University of the Basque Country (UPV/EHU), the Spanish Ministry of Universities and the European Union (Next Generation EU) for his Maria Zambrano postdoctoral fellowship. Mikel Musatadi also thanks the Basque Government for his predoctoral fellowship.
DS Minerva
RD 3 may 2026