RT Journal Article
T1 Filtering the NMR Spectra of Mixtures by Coordination to Paramagnetic Cu2+
A1 Correa, Juan
A1 García Barandela, Ana
A1 Socias, Llorenç
A1 Fernández Megía, Eduardo
AB The paramagnetic spin relaxation (PSR) filter allows the selective NMR signal suppression of components in mixtures according to their complexation ability to a paramagnetic ion. It relies on the faster relaxation of nuclei in paramagnetic environments and thus is complementary to classical diffusion and relaxation filters. So far, the PSR filter has established Gd3+ as the sole PSR agent, restricting the paramagnetic filtering repertoire. Herein, we present Cu2+ as a robust PSR agent with characteristic filtering properties. While Gd3+ depends on unspecific ion-pair interactions with anionic components, Cu2+ stands out for filtering species via ordered coordination complexes. An evaluation of the paramagnetic effect of Cu2+ over more than 50 small molecules and polymers has unveiled different sensitivities to Cu2+ (especially high for pyridines, diamines, polyamines, and amino alcohols) and precise filtering conditions for mixtures (1H, COSY, and HMQC) that were challenged with a test bed of commercial drugs. The advantage of integrating Cu2+ and Gd3+ for the stepwise PSR filtering of complex mixtures is also shown
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29189
UL http://hdl.handle.net/10347/29189
LA eng
NO Anal. Chem. 2022, 94, 31, 10907–10911. https://doi.org/10.1021/acs.analchem.2c01983
NO This work was supported by the Spanish Ministry of Science and Innovation (and PID2021-127684OB-I00), the Xunta de Galicia (ED431C 2018/30, and Centro singular de investigación de Galicia accreditation 2019–2022, ED431G2019/03), Axencia Galega de Innovación (IN845D 2020/09), and the European Union (European Regional Development Fund-ERDF).
DS Minerva
RD 4 may 2026