RT Journal Article
T1 The multifaceted roles of gasdermins in cancer biology and oncologic therapies
A1 Sarrió, David
A1 Martínez-Val, Jeannette
A1 Molina Crespo, Ángela
A1 Sánchez Piñón, Laura
A1 Moreno-Bueno, Gema
K1 Gasdermin
K1 Pyroptosis
K1 Cancer cell death
K1 Cancer treatment
K1 Inflammation
AB The involvement of the Gasdermin (GSDM) protein family in cancer and other pathologies is one of the hottesttopics in biomedical research. There are six GSDMs in humans (GSDMA, B, C, D, GSDME/DFNA5 and PJVK/DFNB59) and, except PJVK, they can trigger cell death mostly by pyroptosis (a form of lytic and proinflammatorycell death) but also other mechanisms. The exact role of GSDMs in cancer is intricate, sincedepending on the biological context, these proteins have diverse cell-death dependent and independent functions,exhibit either pro-tumor or anti-tumor functions, and promote either sensitization or resistance to oncologictreatments. In this review we provide a comprehensive overview on the multifaceted roles of the GSDMs incancer, and we critically discuss the possibilities of exploiting GSDM functions as determinants of anti-cancertreatment and as novel therapeutic targets, with special emphasis on innovative GSDM-directed nano-therapies.Finally, we discuss the issues to be resolved before GSDM-mediated oncologic therapies became a reality atthe clinical level.
PB Elsevier
SN 1879-2561
YR 2021
FD 2021
LK http://hdl.handle.net/10347/31975
UL http://hdl.handle.net/10347/31975
LA eng
NO Sarrió, D., Martínez-Val, J., Molina-Crespo, Á., Sánchez, L., & Moreno-Bueno, G. (2021). The multifaceted roles of gasdermins in cancer biology and oncologic therapies. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(2), 188635
NO This study was supported by the Ministerio de Ciencia e Innovación (PID2019-104644RB-I00 -GMB-), the Instituto de Salud Carlos III (CIBERONC, CB16/12/00295 –GMB-; partly supported by FEDER funds) and by the Fundación Científica de la AECC (FC_AECC PROYE19036MOR -GMB-).
DS Minerva
RD 30 abr 2026