RT Journal Article
T1 Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms
A1 Carrillo Carrión, Carolina
K1 Metal–organic framework
K1 Nanoscale
K1 Drug delivery
K1 Theranostics
K1 Stimuli-responsive
AB Metal–organic frameworks (MOFs) have emerged as one of the most fascinating libraries of porous materials with a huge potential in very diverse application areas. In particular, the bioanalytical and biomedical fields have evolved tremendously due to the emergence of these hybrid inorganic–organic MOF-based materials. This is because these materials possess a series of key properties essential for bioapplications, such as minimal toxicity to living cells, intrinsic biodegradability, and possibility of synthesizing with nanoscale sizes. Additional properties of MOFs such as ultra-large surface-to-volume ratios, tunable pore size, high drug loading capacity, tunable structure and chemical composition, and potential for multiple postsynthetic modification make them ideal candidates for drug delivery. This review highlights recent research progress on MOF-based drug delivery systems (DDS), pointing out the evolution of these systems toward the development of theranostic nanoplatforms. Rather than a comprehensive review, representative recent examples are selected to illustrate such an evolution, and a critical discussion of the advantages and limitations of the different DDS types is given. Finally, the remaining challenges and future opportunities in this field are presented, highlighting that overcoming the current issues will pave the way toward the elusive dream of “personalized medicine.”
PB Springer
SN 1618-2642
YR 2020
FD 2020-01
LK http://hdl.handle.net/10347/20625
UL http://hdl.handle.net/10347/20625
LA eng
NO Carrillo-Carrión, C. Anal Bioanal Chem (2020) 412: 37. https://doi.org/10.1007/s00216-019-02217-y
NO This is a post-peer-review, pre-copyedit version of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at: https://doi.org/10.1007/s00216-019-02217-y
NO C.C.C. thanks the financial support from the European Union under the H2020-MSCA-IF-2016 program (MSCA-IF-EF-ST Grant Agreement No. 749667)
DS Minerva
RD 24 abr 2026