RT Journal Article
T1 SFRP1-silencing GapmeR-loaded lipid-polymer hybrid nanoparticles for bone regeneration in osteoporosis: effect of dosing and targeting strategy
A1 Briffault, Erik
A1 Reyes, Ricardo
A1 García García, Patricia
A1 Rouco Taboada, Helena
A1 Díaz Gómez, Luis
A1 Arnau, María Rosa
A1 Évora, Carmen
A1 Díaz Rodríguez, Patricia
A1 Delgado, Araceli
K1 Osteoporosis
K1 Bone targeting
K1 Nanoparticle dose-effect
K1 Gene therapy
K1 Aptamer
K1 Alendronate
K1 Micro-CT
AB Osteoporosis is a metabolic disorder characterized by the loss of bone mass and density. Nucleic acid-based therapies are among the most innovative approaches for osteoporosis management, although their effective delivery to bone tissue remains a challenge. In this work, SFRP1-silencing GampeR loaded-nanoparticles were prepared and functionalized with specific moieties to improve bone targeting and, consequently, therapeutic efficacy. SFRP1-silencing would promote osteoblastic differentiation by enhancing the WNT/β-catenin pathway and thus diminishing the progression of osteoporosis.
PB Taylor & Francis
YR 2024
FD 2024-11-20
LK https://hdl.handle.net/10347/43674
UL https://hdl.handle.net/10347/43674
LA eng
NO Briffault E, Reyes R, Garcia-Garcia P, Rouco H, Diaz-Gomez L, Arnau MR, Evora C, Diaz-Rodriguez P, Delgado A. SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy. Int J Nanomedicine. 2024;19:12171-12188 https://doi.org/10.2147/IJN.S476546
NO E.B. thanks the Canary Islands Agency for Research, Innovation and Information Society (ACIISI) of the Counseling of Economy, Knowledge and Employment and the European Social Fund (ESF) Integrated Operational Program of the Canary Islands 2014–2020 for his predoctoral grant (TESIS2022010094).
DS Minerva
RD 27 abr 2026