RT Journal Article
T1 1D alignment of proteins and other nanoparticles by using reversible covalent bonds on cyclic peptide nanotubes
A1 Priegue Caamaño, Juan Manuel
A1 Louzao Pernas, Iria
A1 Gallego Gómez, Iván
A1 Montenegro García, Javier
A1 Granja Guillán, Juan Ramón
AB Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely controlled. In this communication we describe a general strategy to align different molecules on top of the nanotube surface by using cyclic peptides bearing chemoreversible reactive groups. D,L-α-Cyclic peptides endowed with a hydrazide moiety were condensed with a pyrenecarboxyaldehyde to facilitate the nanotube formation and deposition on flat unfunctionalized surfaces. The hydrazide moieties can be liberated without affecting the tubular structure and then used to align on top of the nanotube other molecules bearing aldehyde functions. Additionally, the attachment of specific ligands allowed the supramolecular alignment of corresponding receptors, such as mannosyl aldehyde and concavaline-A, driven by the nanotube structure through complemetary protein–ligand interactions
PB Royal Society of Chemistry
SN 2052-4110
YR 2021
FD 2021
LK http://hdl.handle.net/10347/29370
UL http://hdl.handle.net/10347/29370
LA eng
NO Org. Chem. Front., 2022,9, 1226-1233 https://doi.org/10.1039/D1QO01349A
NO This work was supported by the Spanish Agencia Estatal de Investigación (AEI) and the ERDF (PID2019 111126RB-100, SAF2017-89890-R, EIG_JC2018-054), and by the Xunta de Galicia and the ERDF (ED431C 2017/25 and Centro singular de Investigación de Galicia accreditation 2019-2022, ED431G2019/03). We also thank the ORFEO-CINCA network and Mineco (RED2018-102331-T). J.M.P. thanks to the Ministerio de Educación y Cultura (MEC) for his FPI contract. J.M. received an ISCIII (COV20/00297), ERC - Stg (DYNAP-677786), ERC-PoC (TraffikGene, 838002),and a YIG from the HFSP (RGY0066/2017)
DS Minerva
RD 28 abr 2026