RT Journal Article
T1 3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering
A1 Iglesias-Mejuto, Ana
A1 García González, Carlos A.
K1 3D-printing
K1 Supercritical drying
K1 Aerogel
K1 Bone scaffold
K1 Hydroxyapatite
AB 3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries and compositions by depositing materials layer-by-layer with high precision. For these purposes, the production of bioactive gel-based 3D-scaffolds made of biocompatible materials with well-defined internal structure comprising a dual (mesoporous and macroporous) and highly interconnected porosity is essential. In this work, aerogel scaffolds for bone regeneration purposes were obtained by an innovative strategy that combines the 3D-printing of alginate-hydroxyapatite (HA) hydrogels and the supercritical CO2 drying of the gels. BET and SEM analyses were performed to assess the textural parameters of the obtained aerogel scaffolds and the dimensional accuracy to the original computer-aided design (CAD) design was also evaluated. The biological characterization of the aerogel scaffolds was also carried out regarding cell viability, adhesion and migration capacity. The obtained alginate-HA aerogel scaffolds were highly porous, biocompatible, with high fidelity to the CAD-pattern and also allowed the attachment and proliferation of mesenchymal stem cells (MSCs). An enhancement of the fibroblast migration toward the damaged area was observed in the presence of the aerogel formulations tested, which is positive in terms of bone regeneration
PB Elsevier
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27656
UL http://hdl.handle.net/10347/27656
LA eng
NO Materials Science and Engineering: C 131 (2021) 112525. https://doi.org/
NO This work was supported by Xunta de Galicia [ED431C 2020/17], MICINN [PID2020-120010RB-I00], Agencia Estatal de Investigación [AEI] and FEDER funds. Work carried out in the framework of the COST Action CA18125 “Advanced Engineering and Research of aeroGels for Environment and Life Sciences” (AERoGELS) and funded by the European Commission. A.I.-M. acknowledges to Xunta de Galicia for her predoctoral research fellowship [ED481A- 2020/104]. A. Alonso is commended for his technical contribution to this work
DS Minerva
RD 28 abr 2026