RT Journal Article
T1 Zoanthamine alkaloids from the zoantharian zoanthus cf. pulchellus and their effects in neuroinflammation
A1 Guillen, Paul O.
A1 Gegunde Mosquera, Sandra
A1 Jaramillo, Karla B.
A1 Alfonso Rancaño, María Amparo
A1 Calabro, Kevin
A1 Alonso López, Eva
A1 Rodriguez, Jenny
A1 Botana López, Luis Miguel
A1 Thomas, Olivier P.
K1 Zoantharia
K1 Tropical Eastern Pacific
K1 Zoanthus pulchellus
K1 Zoanthamine
K1 Inflammation
AB Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation
PB MDPI
YR 2018
FD 2018
LK http://hdl.handle.net/10347/22505
UL http://hdl.handle.net/10347/22505
LA eng
NO Guillen, P.O.; Gegunde, S.; Jaramillo, K.B.; Alfonso, A.; Calabro, K.; Alonso, E.; Rodriguez, J.; Botana, L.M.; Thomas, O.P. Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation. Mar. Drugs 2018, 16, 242
NO The project is originally funded by the Secretaria de Educación Superior, Ciencia, Tecnología e Innovación (SENESCYT) in the framework of the PIC-14-CENAIM-001 Project Caracterización de la BiodiversidadMicrobiológica y de Invertebrados de la Reserva Marina “El Pelado” a Escala Taxonómica, Metabolómica yMetagenómica para su Uso en Salud Humana y Animal. Part of this project (Grant-Aid Agreement No. PBA/MB/16/01) is carried out with the support of the Marine Institute and is funded under the MarineResearch Programme by the Irish Government. P.O.G. and K.B.J. acknowledge NUI Galway for supportingpart of their Ph.D. scholarship. The research leading to the results of the biological assays has received fundingfrom the following FEDER cofunded-grants: Consellería de Cultura, Educación e Ordenación Universitaria,Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01); CDTI and Technological Funds, supported byMinisterio de Economía, Industria y Competitividad, AGL2014-58210-R, AGL2016-78728-R (AEI/FEDER, UE),ISCIII/PI16/01830 and RTC-2016-5507-2, ITC-20161072; European Union POCTEP 0161-Nanoeaters-1-E-1,Interreg AlertoxNet EAPA-317-2016, and H2020 778069-EMERTOX
DS Minerva
RD 25 abr 2026