RT Journal Article
T1 Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity
A1 Boente Juncal, Andrea
A1 Vale González, María del Carmen
A1 Cifuentes Martínez, José Manuel
A1 Otero Fuertes, María Paz
A1 Camiña García, María Mercedes
A1 Rodríguez Vieytes, Mercedes
A1 Botana López, Luis Miguel
K1 Tetrodotoxin
K1 Toxicity
K1 European mollusks
K1 Chronic exposure
K1 Risk assessment
AB Tetrodotoxin (TTX) is one of the most potent naturally occurring neurotoxins. Initially TTX was associated with human food intoxications in Japan, but nowadays, concerns about the human health risks posed by TTX have increased in Europe after the identification of the toxin in fish, marine gastropods, and bivalves captured in European waters. Even when TTX monitoring is not currently performed in Europe, an acute oral no observable effect level (NOAEL) of 75 μg/kg has been recently established but, to date, no studies evaluating the chronic oral toxicity of TTX have been released, even when EFSA has highlighted the need for them. Thus, in this work, the chronic effects of low oral TTX doses (below the acute lethal dose 50) were evaluated following internationally adopted guidelines. The results presented here demonstrate that low oral doses of TTX have deleterious effects on renal and cardiac tissues. Moreover, alterations in blood biochemistry parameters, urine production, and urinalysis data were already detected at the oral dose of 75 µg/kg after the 28 days exposure. Thus, the data presented here constitute an initial approach for the chronic evaluation of the in vivo toxicity of tetrodotoxin after its ingestion through contaminated fishery products.
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21202
UL http://hdl.handle.net/10347/21202
LA eng
NO Boente-Juncal, A., Vale, C., Cifuentes, M. et al. (2019). Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity . "Toxins", 11(2), 96
NO The research leading to these results has received funding from the following European Regional Development Fund (FEDER) cofunded grants. From Conselleria de Cultura, Educacion e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01). From the Centre for the Development of Industrial Technology (CDTI) and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad, AGL2014-58210-R, AGL2016-78728-R (AEI/FEDER, UE), ISCIII/PI16/01830 and RTC-2016-5507-2, ITC-20161072. From European Union POCTEP 0161-Nanoeaters-1-E-1, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX.
DS Minerva
RD 28 abr 2026