RT Journal Article
T1 Nanoparticles engineered to bind cellular motors for efficient delivery
A1 Dalmau-Mena, Inmaculada
A1 Pino González de la Higuera, Pablo Alfonso del
A1 Pelaz García, Beatriz
A1 Cuesta-Geijo, Miguel Ángel
A1 Galindo, Inmaculada
A1 Moros, María
A1 Martínez de la Fuente, Jesús
A1 Alonso, Covadonga
K1 Nanoparticles
K1 Biomimetic synthetic peptides
K1 Drug delivery
K1 Microtubule motors
K1 Dynein
AB BackgroundDynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding peptides could be used to functionalize nanoparticles for drug delivery applications.ResultsHere, we show that gold nanoparticles modified with dynein-binding delivery sequences become mobile, powered by molecular motor proteins. Modified nanoparticles showed dynamic properties, such as travelling the cytosol, crossing intracellular barriers and shuttling the nuclear membrane. Furthermore, nanoparticles were transported from one cell to another through cell-to-cell contacts and quickly spread to distant cells through cell projections.ConclusionsThe capacity of these motor-bound nanoparticles to spread to many cells and increasing cellular retention, thus avoiding losses and allowing lower dosage, could make them candidate carriers for drug delivery
PB BioMed Central
SN 1477-3155
YR 2018
FD 2018
LK http://hdl.handle.net/10347/19761
UL http://hdl.handle.net/10347/19761
LA eng
NO Dalmau-Mena, I., del Pino, P., Pelaz, B., Cuesta-Geijo, M., Galindo, I., & Moros, M. et al. (2018). Nanoparticles engineered to bind cellular motors for efficient delivery. Journal Of Nanobiotechnology, 16(1). doi: 10.1186/s12951-018-0354-1
NO The present work was supported by grants from the Spanish Ministry of Economy, Industry and Competiveness AGL2012-34533, AGL2015-69598-R, SAF2014-54763-C2-2-R, Fondo Social de la DGA (grupos DGA), ERC-Starting Grant 239931-NANOPUZZLE and COST Action CA15138 Transautophagy. PdP and BP thanks financial support from the Consellería de Cultura, Educación e Ordenación Universitaria (Centro singular de investigación de Galicia accreditation 2016–2019, ED431G/09), and the European Regional Development Fund (ERDF)
DS Minerva
RD 29 abr 2026