RT Journal Article
T1 A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles
A1 Fernández Villamarín, Marcos
A1 Sousa Hervés, Ana
A1 Porto, Silvia
A1 Guldris, Noelia
A1 Martínez Costas, José Manuel
A1 Riguera Vega, Ricardo
A1 Fernández Megía, Eduardo
AB Polyion complex (PIC) micelles incorporating PEG-dendritic copolymers display an unprecedented stability towards ionic strength that is amplified via hydrophobic interactions. The tridimensional orientation of peripheral hydrophobic linkers between charged groups and the globular/rigid dendritic scaffold maximizes this stabilization compared to PIC micelles from linear polymers. As a result, micelles stable at concentrations higher than 3 M NaCl are obtained, which represents the highest saline concentration attained with PIC micelles. Advantages of this stabilizing dendritic effect have been taken for the design of a robust, pH-sensitive micelle for the controlled intracellular release of the anticancer drug doxorubicin. This micelle displays a slightly higher toxicity, and distinctive mechanisms of cell uptake and intracellular trafficking relative to the free drug. The preparation of mixed PIC micelles by combining differently functionalized PEG-dendritic block copolymers has allowed the fine-tuning of their stability, paving the way towards the facile modulation of properties like biodegradability, drug loading, or the response to external stimuli
PB Royal Society of Chemistry
YR 2017
FD 2017-03-28
LK http://hdl.handle.net/10347/16976
UL http://hdl.handle.net/10347/16976
LA eng
NO Fernandez-Villamarin, M., Sousa-Herves, A., Porto, S., Guldris, N., Martínez-Costas, J., Riguera, R., & Fernandez-Megia, E. (2017). A dendrimer–hydrophobic interaction synergy improves the stability of polyion complex micelles. Polym. Chem., 8(16), 2528-2537. doi: 10.1039/c7py00304h
NO This work was financially supported by the Spanish Ministry ofEconomy, Industry and Competitiveness (MINECO) (CTQ2015‐69021‐R), the Consellería de Cultura, Educación e OrdenaciónUniversitaria (GRC2014/040 and Centro Singular deInvestigación de Galicia Accreditation 2016‐2019, ED431G/09),and the European Regional Development Fund (ERDF). M.F.‐V.thanks the Spanish Government for a FPU Fellowship
DS Minerva
RD 28 abr 2026