RT Journal Article
T1 Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia
A1 Mosquera Orgueira, Adrián
A1 Peleteiro Raíndo, Andrés
A1 Cid López, Miguel
A1 Antelo Rodríguez, Beatriz
A1 Díaz Arias, José Ángel
A1 Ferreiro Ferro, Roi
A1 Alonso Vence, Natalia
A1 Bendaña López, Ángeles
A1 Abuín Blanco, Aitor
A1 Bao Pérez, Laura
A1 Melero Valentín, Paula
A1 González Pérez, Marta Sonia
A1 Cerchione, Claudio
A1 Martinelli, Giovanni
A1 Montesinos Fernández, Pau
A1 Pérez Encinas, Manuel Mateo
A1 Bello López, José Luis
K1 Acute myeloid leukemia
K1 FLT3 mutation-like
AB BackgroundFLT3 mutation is present in 25–30% of all acute myeloid leukemias (AML), and it is associated with adverse outcome. FLT3 inhibitors have shown improved survival results in AML both as upfront treatment and in relapsed/refractory disease. Curiously, a variable proportion of wild-type FLT3 patients also responded to these drugs.MethodsWe analyzed 6 different transcriptomic datasets of AML cases. Differential expression between mutated and wild-type FLT3 AMLs was performed with the Wilcoxon-rank sum test. Hierarchical clustering was used to identify FLT3-mutation like AMLs. Finally, enrichment in recurrent mutations was performed with the Fisher’s test.ResultsA FLT3 mutation-like gene expression pattern was identified among wild-type FLT3 AMLs. This pattern was highly enriched in NPM1 and DNMT3A mutants, and particularly in combined NPM1/DNMT3A mutants.ConclusionsWe identified a FLT3 mutation-like gene expression pattern in AML which was highly enriched in NPM1 and DNMT3A mutations. Future analysis about the predictive role of this biomarker among wild-type FLT3 patients treated with FLT3 inhibitors is envisaged.
PB Public Library Science
SN 1932-6203
YR 2021
FD 2021-02-16
LK https://hdl.handle.net/10347/42537
UL https://hdl.handle.net/10347/42537
LA eng
NO Mosquera Orgueira A, Peleteiro Raíndo A, Cid López M, Antelo Rodríguez B, Díaz Arias JÁ, Ferreiro Ferro R, et al. Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia. Bertolini F, editor. PLOS ONE. 2021 Feb 16;16(2):e0247093
DS Minerva
RD 28 abr 2026