RT Book,_Section
T1 Epigenetic aging and its reversal
A1 Parte, Cristina de la
A1 Guallar Artal, Diana
A2 Fang, Evandro Fei
A2 Bergersen, Linda Hildegard
A2 Gilmour, Brian C.
K1 Epigenetics
K1 Aging
K1 Healthy ageing
AB Aging is characterized by a loss of molecular fidelity that leads to cellular dysfunction and culminates in disease and death. Understanding the molecular mechanisms underlying this physiologic process is important to developing rejuvenation strategies and therapeutic interventions. Aging is associated with changes in the epigenome, including changes in DNA methylation, imbalance in histone repression and activating marks, alteration of chromatin condensation and nuclear architecture, and with changes in the expression of noncoding RNAs. In this chapter, we review the current understanding of epigenetic alterations and mechanisms described regarding aging in humans. We summarize their contribution to the aging process, epigenetic rejuvenation interventions and their therapeutic potential, and open questions that remain to be addressed to have a more complete picture of the epigenome involvement in human aging.
PB Elsevier Academic Press
SN 9780323916172
YR 2023
FD 2023-01
LK https://hdl.handle.net/10347/42593
UL https://hdl.handle.net/10347/42593
LA eng
NO De la Parte C, Guallar D. Epigenetic aging and its reversal. In: Fang EF, Bergersen LH, and Gilmour BC (eds). Molecular, Cellular, and Metabolic Fundamentals of Human Aging. San Diego: Elsevier Inc./Academic Press, 2022: pp.9-38.
DS Minerva
RD 28 abr 2026