RT Dissertation/Thesis
T1 Identification and regulation of epicardial adipose tissue biomarkers in atrial fibrillation
A1 Couselo Seijas, Marinela
K1 epicardial adipose tissue
K1 atrial fibrillation
K1 FABP4
K1 acetylcholine
K1 Ca2+
AB Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It isa multifactorial disease aggravated by a myriad of pathophysiological mechanisms. Among its risk factors,hypertension, heart failure and obesity are the main ones. The local adipose depot most associated with AF is theepicardial adipose tissue (EAT). One of the promoter events of AF is the alteration in the autonomic tone and one ofthe favouring substrates is inflammation. Our aim was to study the mechanisms of acetylcholine (ACh) in EAT andits relationship with AF. Our results showed the expression of muscarinic receptors in EAT stromal cells and itsregulation during adipogenesis. The results of this work elucidate the role of the cholinergic system in the secretoryand inflammatory activity of EAT (through IL-6, MCP1 and DEFA3) and a possible mechanism associated withpostoperative AF. In addition, Chronic cholinergic imbalance in long-term persistent AF could explain the greateraccumulation of fatty acids. Consequently, FABP4 increases in the epicardial stroma. Our results showed thatFABP4 induces in hiPSC-derived atrial cardiomyocytes changes in calcium handling.
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29266
UL http://hdl.handle.net/10347/29266
LA eng
DS Minerva
RD 24 abr 2026