RT Journal Article
T1 Changes in brain activity related to episodic memory retrieval in adults with single domain amnestic mild cognitive impairment
A1 Rivas Fernández, Miguel Ángel
A1 Lindín Novo, Mónica
A1 Díaz Fernández, Fernando
A1 Zurrón Ocio, Montserrat
A1 Galdo Álvarez, Santiago
K1 Alzheimer´s disease
K1 Brain activity changes
K1 Episodic memory
K1 Functional magnetic resonance imaging (fMRI)
K1 Single domain amnestic mild cognitive impairment (sdaMCI)
AB The present fMRI study aimed to characterize the performance and the brain activity changes related to episodic memory retrieval in adults with single domain aMCI (sdaMCI), relative to cognitively unimpaired adults. Participants performed an old/new recognition memory task with words while BOLD signal was acquired. The sdaMCI group showed lower hits (correct recognition of old words), lower ability to discriminate old and new words, higher errors and longer reaction times for hits. This group also displayed brain hypoactivation in left precuneus and the left midcingulate cortex during the successful recognition of old words. These changes in brain activity suggest the presence of neural dysregulations in brain regions involved during successful episodic memory retrieval. Moreover, hypoactivation in these brain areas discriminated both groups with moderate sensitivity and specificity values, suggesting that it might constitute a potential neurocognitive biomarker of sdaMCI.
PB Elsevier
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27518
UL http://hdl.handle.net/10347/27518
LA eng
NO Rivas-Fernández, M. Á., Lindín, M., Díaz, F., Zurrón, M., & Galdo-Álvarez, S. (2021). Changes in brain activity related to episodic memory retrieval in adults with single domain amnestic mild cognitive impairment. Biological Psychology, 166, 108208
NO This study was supported by grants from the Spanish Government, Ministerio de Economía y Competitividad (PSI2014–55316-C3–3-R; PSI2017–89389-C2–2-R; PID2020–114521RB-C21/C22); and the Galician Government, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC. Ref: ED431–2017/27; ED431C-2021/04. All with ERDF/FEDER funds
DS Minerva
RD 27 abr 2026