RT Journal Article
T1 Study on the chemical behaviour of Bisphenol S during the in vitro gastrointestinal digestion and its bioaccessibility
A1 Lestido Cardama, Antía
A1 Millán Sánchez, Beatriz
A1 Sendón García, Raquel
A1 Rodríguez Bernaldo de Quirós, Ana Isabel
A1 Barbosa Pereira, Letricia
K1 Bisphenol S
K1 In vitro gastrointestinal digestion
K1 Bioaccessibility
K1 Soy drink
K1 Food packaging
K1 HPLC-PDA-MS/MS
AB This study evaluated the chemical behaviour of Bisphenol S (BPS) and determined its bioaccessibility after human ingestion using a standardised in vitro gastrointestinal digestion protocol and an analytical method based on high-pressure liquid chromatography coupled with a photodiode array and tandem mass spectrometry. The effects of different factors such as gastric pH, enzymes, and food matrix on the solubility and chemical stability of BPS were studied to evaluate their contribution to its bioaccessibility. The results highlighted that BPS was available at the end of the digestion process in the range of 50–80%, and was susceptible to absorption at the intestinal level. The effect of pH was not significant as a single factor. The presence of enzymes slightly decreased the bioaccessibility of BPS in the intestinal phase with gastric pH increase. Additionally, a soy drink reduced BPS bioaccessibility by up to 5% after oral intake. Finally, a few BPS degradation products were found in non-bioaccessible fractions at different pH values
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27331
UL http://hdl.handle.net/10347/27331
LA eng
NO Food Chemistry 367 (2022) 130758
NO This research was funded the “Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia”, within the project “Consolidación y estructuración de unidades de investigación competitivas—Grupos de referencia competitiva (GRC)” (Ref. GRC 2019/030). L. Barbosa-Pereira is grateful to the Spanish Ministry of Science, Innovation and Universities for her “Juan de la Cierva – Incorporación” Grant (Agreement No. IJCI-2017-31665). Antía Lestido-Cardama is grateful for her grant “Programa de axudas á etapa predoutoral” da Xunta de Galicia (Consellería de Cultura, Educación e Ordenación Universitaria
DS Minerva
RD 24 abr 2026